TITLE

The social functional outcome of being naturalistically treated with paliperidone extended-release in patients with schizophrenia

AUTHOR(S)
Ryoko Nakagawa; Takashi Ohnishi; Hisanori Kobayashi; Akihide Wakamatsu; Ai Tanimura; Kazuo Morita; Toshio Yamaoka; Hideo Usui; Yoshimasa Ogawa; Akiko Fujino; Kazutake Yoshizawa
PUB. DATE
June 2015
SOURCE
Neuropsychiatric Disease & Treatment;Jun2015, Vol. 11, p1511
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Social functioning is an important outcome for patients with schizophrenia. To evaluate the effects of paliperidone extended-release (PAL-ER) on social function, symptomatology, and safety in the routine clinical practice, we conducted a 1-year post-marketing surveillance study of PAL-ER. We also explored relationships between symptomatic improvement and socially functional outcome in patients with schizophrenia. Patients and methods: Patients with an established diagnosis of schizophrenia were allowed flexible 3-12 mg/day dosing during the surveillance. Patients were assessed on social functioning using the Social and Occupational Functioning Assessment Scale (SOFAS) and on symptomatology using the Clinical Global Impression-Schizophrenia scale. All adverse events (AEs) were also collected. Results: A total of 1,429 patients were enrolled in the surveillance study, of whom 1,405 were evaluable for safety and 1,142 were evaluable for efficacy. The treatment discontinuation rate for any reason during the observation period was 34.66%. Significant improvements were observed on both Social and Occupational Functioning Assessment Scale and Clinical Global Impression-Schizophrenia scale during the observation period. The percentage of patients with socially functional remission (SOFAS ≥61) also increased significantly. A significant association between early improvements in positive symptoms, sex, severity of negative symptoms at baseline, and socially functional remission was observed. A total of 33.52% of patients had AEs and 8.75% of patients had serious AEs. Despite the recommendation of monotherapy with PAL-ER, 65.84% of patients were given additional antipsychotics (polypharmacy). Post hoc comparisons of monotherapy versus polypharmacy revealed that the monotherapy group had better outcomes and fewer AEs than the polypharmacy treated group. The improvement in social functioning and the rate of socially functional remission did not differ between groups. Conclusion: PAL-ER treatment showed effective symptom control and improvement in social functioning. The data suggest that early response to antipsychotic treatment should be important for functional outcomes.
ACCESSION #
108380847

 

Related Articles

  • The Danish Schizophrenia Registry. Baandrup, Lone; Cerqueira, Charlotte; Haller, Lea; Korshøj, Lene; Voldsgaard, Inge; Nordentoft, Merete // Clinical Epidemiology;Oct2016, Vol. 8, p691 

    Aim of database: To systematically monitor and improve the quality of treatment and care of patients with schizophrenia in Denmark. In addition, the database is accessible as a resource for research. Study population: Patients diagnosed with schizophrenia and receiving mental health care in...

  • Future of the Chronic Schizophrenic Patient: Prediction and Recommendations. Gralnick, Alexander // American Journal of Psychotherapy;Jul1986, Vol. 40 Issue 3, p418 

    Presents an historical sketch of psychiatry and the many factors which finally led from the zenith of the state hospital system in the 1940s to the deinstitutionalization process and its consequences in the U.S. Predictions about the future diagnosis, care and treatment of schizophrenic...

  • Treatment Guidelines for Patients with Schizophrenia or Psychotic Disorder who are Hospitalized in a Psychiatry Clinic. Alptekin, Koksal; Ucok, Alp; Ayer, Ahmet; Unal, Ahmet; Erol, Atila; Ensari, Hulya; Atmaca, Murad; Ozguven, Halise Devrimci // Klinik Psikofarmakoloji Bulteni;2014, Vol. 24 Issue 3, p276 

    In schizophrenia, hospitalization is generally indicated for patients who pose a serious threat to themselves or others, those who are disorganized to the extent of not to being able to look after themselves or who are experiencing delusions/hallucinations. The steps to be taken during the time...

  • Metaanálisis de la rehabilitación cognitiva en la esquizofrenia. McGurk, Susan R.; Twamley, Elizabeth W.; Sitzer, David I.; McHugo, Gregory J.; Mueser, Kim T. // American Journal of Psychiatry - Edición Española;Mar2008, Vol. 11 Issue 3, p145 

    No abstract available.

  • A composite scale applied to evaluate anxiety in schizophrenic patients (SAES). Llorca, Pierre-Michel; Lancon, Christophe; Blanc, Olivier; Chazeron, Ingrid; Samalin, Ludovic; Caci, Hervé; Lesturgeon, Jean-Alexandre; Bayle, Franck // European Archives of Psychiatry & Clinical Neuroscience;Mar2014, Vol. 264 Issue 2, p171 

    Anxiety in schizophrenia possesses specific features and is difficult to assess because no specific evaluating tool is currently available. The aim of this study was to develop and validate a hetero-assessment-based scale to specifically measure anxiety in schizophrenia. A literature review and...

  • Factors associated with use of community mental health services by schizophrenia patients using multilevel analysis.  // BMC Health Services Research;2011 Supplement 1, Vol. 11 Issue Suppl 1, p257 

    The article presents a study that identified the factors associated with community mental health services of patients with schizophrenia. The cross-sectional method was used to analyze the patients and multilevel linear regression model showed the variance between patients contacted with...

  • Prädeliktische Behandlungswege schizophrener Patienten der forensischen Psychiatrie. Piontek, K.; Kutscher, S.-U.; König, A.; Leygraf, N. // Der Nervenarzt;Jan2013, Vol. 84 Issue 1, p55 

    Background: The number of schizophrenic patients admitted to forensic hospitals according to section 63 of the German Criminal Code has increased continuously over the past years. Prior to admission to a forensic ward, two thirds of schizophrenic patients have been admitted to a general...

  • Assessment of drug attitudes in patients with schizophrenia: psychometric properties of the DAI Spanish version.  // Actas Espanolas de Psiquiatria;may2004, Vol. 32 Issue 3, p138 

    INTRODUCTION: The aim of the present study was to translate into Spanish and evaluate interrater reliability, internal consistency, and convergent validity with the Insight Treatment Questionnaire (ITAQ) and Buchanan's compliance measure, and their relation with sociodemographic and clinical...

  • The expectation of outcome from maintenance therapy in chronic schizophrenic patients. Johnson, D. A. W.; Johnson, D A // British Journal of Psychiatry;Mar76, Vol. 128, p246 

    The results from a prospective follow-up study of a group of schizophrenic patients suggest that a significant proportion (41 per cent) are likely to relapse during a two-year period despite the prescription of long-acting injectable neuroleptic drugs. Some will relapse because of a failure of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics