Reply to SE Langabeer et al
Tags: MUTATION (Biology); TRISOMY; AMINO acids; MYELOID leukemia; PROTEIN kinases; POLYMERASE chain reaction
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Tetraploidy and near-tetraploidy are rare in acute myeloid leukemia (AML), contrary to other hematological disease. In this paper we describe a case of a 52-year-old male with AML associated with tetraploidy, mutation in tyrosine kinase receptor FLT3, and very short survival. At presentation...
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Background Mutations within the FLT3 gene, which code for the class-III-receptor kinase FLT3, ranked within the most frequent recurrent known genetic markers in acute myelocytic leukemia (AML). Internal tandem duplication (ITD) mutations in the juxtamembrane domain of FLT3 gene occur in 20-25%...
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Background: BCR-ABL kinase domain (KD) mutation is the major mechanism contributing to suboptimal response to tyrosine kinase inhibitors (TKI) in BCR-ABL-positive chronic myeloid leukemia (CML) patients. T315I mutation, as one of the most frequent KD mutations, has been shown to be strongly...
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A descriptive cross-sectional study was conducted on chronic myeloid leukemia (CML) patients who attended to the Radio-isotope center in Khartoum (RICK) , Sudan; in the period from June 2006 up to December 2008. 50 cDNA samples from Philadelphia positive CML patients; were chosen from DNAs of...
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A descriptive cross-sectional study was conducted on chronic myeloid leukemia (CML) patients who attended to the Radio-isotope center in Khartoum (RICK) , Sudan; in the period from June 2006 up to December 2008. 50 cDNA samples from Philadelphia positive CML patients; were chosen from DNAs of...
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The identification of prognostically relevant fusion genes is required in the routine diagnostic process of most advanced clinical protocols for leukemia patients, either for risk stratification, target-specific treatments, and/or as markers for monitoring Minimal Residual Disease during...
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Mutations in exon 12 of the nucleophosmin (NPM1) gene occur in about 60% of adult AML with normal karyotype. By exploiting a specific feature of NPM1 mutants, that is insertion at residue 956 or deletion/insertion at residue 960, we developed highly sensitive, real-time quantitative (RQ)...
