Occipital hypoperfusion in ParkinsonÂ’s disease without dementia: correlation to impaired cortical visual processing

G. Sobue; Y. Abe; T. Kachi; T. Kato; Y. Arahata; T. Yamada; Y. Washimi; K. Iwai; K. Ito; N. Yanagisawa
April 2003
Journal of Neurology, Neurosurgery & Psychiatry;Apr2003, Vol. 74 Issue 4, p419
Academic Journal
Objective: The purpose of this study was to analyse changes in regional cerebral blood flow (rCBF) in Parkinson's disease (PD) without dementia. Methods: Twenty eight non-demented patients with PD and 17 age matched normal subjects underwent single photon emission computed tomography with N-isopropyl-p-[123I]iodoamphetamine to measure rCBF. The statistical parametric mapping 96 programme was used for statistical analysis. Results: The PD patients showed significantly reduced rCBF in the bilateral occipital and posterior parietal cortices (p<0.01, corrected for multiple comparison p<0.05), when compared with the control subjects. There was a strong positive correlation between the score of Raven's coloured progressive matrices (RCPM) and the rCBF in the right visual association area (p<0.01, corrected for multiple comparison p<0.05) among the PD patients. Conclusions: This study showed occipital and posterior parietal hypoperfusion in PD patients without dementia. Furthermore, it was demonstrated that occipital hypoperfusion is likely to underlie impairment of visual cognition according to the RCPM test, which is not related to motor impairment.


Related Articles

  • Geographical distribution of amyotrophic lateral sclerosis with neurofibrillary tangles in the Kii peninsula of Japan. Kokubo, Yasumasa; Kuzuhara, Shigeki; Narita, Yugo // Journal of Neurology;Nov2000, Vol. 247 Issue 11, p850 

    Between 1984 and 1996 we histopathologically examined 26 autopsy cases of amyotrophic lateral sclerosis (ALS) from the Mie Prefecture in eastern and southern Kii Peninsula, which includes the Hohara ALS focus. Four of the individuals had a moderate number of neurofibrillary tangles in the locus...

  • Factors associated with drug–induced visual hallucinations in Parkinson's disease. Papapetropoulos, Spiridon; Argyriou, Andreas A.; Ellul, John // Journal of Neurology;Oct2005, Vol. 252 Issue 10, p1223 

    Aims Visual hallucinations are common in medication-treated Parkinson's disease (PD) patients. Although their etiology is unknown several factors seem to be involved in their pathogenesis. The aim of this study was to identify possible risk factors and determine clinical characteristics...

  • The pattern of cortical atrophy in Parkinson's disease with mild cognitive impairment according to the timing of cognitive dysfunction. Lee, Ji; Cho, Kyoo; Kim, Myonghwan; Sohn, Young; Lee, Phil // Journal of Neurology;Mar2012, Vol. 259 Issue 3, p469 

    The density of Lewy bodies or the concurrent β-amyloid pathology would act as modulators in the relative timing of dementia during the course of Parkinson's disease. Depending on the temporal relationship between the onset of parkinsonism and that of cognitive impairment, patients with...

  • Similar early clinical presentations in familial and non-familial frontotemporal dementia. Piguet, O.; Brooks, W. S.; Halliday, G. M.; Schofield, P. R.; Stanford, P. M.; Kwok, J. B. J.; Spillontini, M-G.; Yancopoulou, D.; Nestor, P. J.; Broe, G. A.; Hodges, J. R. // Journal of Neurology, Neurosurgery & Psychiatry;Dec2004, Vol. 75 Issue 12, p1743 

    Background: It is unclear whether there are early clinical features that can distinguish between patients with familial and non-familial frontotemporal dementia (FTD) Objective: To compare the clinical features of FTD cases who have tau gene mutations with those of cases with a family history of...

  • Neurodegenerative disorders: Parkinson's disease and Huntington's disease. Hague, S. M.; Klaffke, S.; Bandmann, O. // Journal of Neurology, Neurosurgery & Psychiatry;Aug2005, Vol. 76 Issue 8, p1058 

    Parkinson's disease and Huntington's disease are both model diseases. Parkinson's disease is the most common of several akinetic-rigid syndromes and Huntington's disease is only one of an ever growing number of trinucleotide repeat disorders. Molecular genetic studies and subsequent molecular...

  • The utility of the Cambridge Behavioural Inventory in neurodegenerative disease. Wedderburn, C.; Wear, H.; Brown, J.; Mason, S. J.; Barker, R. A.; Hodges, J.; Williams-Gray, C. // Journal of Neurology, Neurosurgery & Psychiatry;May2008, Vol. 79 Issue 5, p500 

    We investigated the utility of the Cambridge Behavioural Inventory (CBI), a carer-completed questionnaire, in a large cohort with Parkinson's disease (PD) (n = 215). In a sub-cohort of 112 patients with PD, the CBI was found to be a valid instrument compared with the Neuropsychiatric Inventory,...

  • The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family. Salvatore Spina; Martin R. Farlow; Frederick W. Unverzagt; David A. Kareken; Jill R. Murrell; Graham Fraser; Francine Epperson; R. Anthony Crowther; Maria G. Spillantini; Michel Goedert; Bernardino Ghetti // Brain: A Journal of Neurology;Jan2008, Vol. 131 Issue 1, p72 

    Multiple system tauopathy with presenile dementia (MSTD) is an inherited disease caused by a (g) to (a) transition at position +3 in intron 10 of Tau. It belongs to the spectrum of frontotemporal dementia and parkinsonism linked to chromosome 17 with mutations in Tau (FTDP-17T). Here we present...

  • A novel locus for dementia with Lewy bodies: a clinically and genetically heterogeneous disorder. Veerle Bogaerts; Sebastiaan Engelborghs; Samir Kumar-Singh; Dirk Goossens; Barbara Pickut; Julie van der Zee; Kristel Sleegers; Karin Peeters; Jean-Jacques Martin; Jurgen Del-Favero; Thomas Gasser; Dennis W. Dickson; Zbigniew K. Wszolek; Peter P. De Deyn; Jessie Theuns; Christine Van Broeckhoven // Brain: A Journal of Neurology;Sep2007, Vol. 130 Issue 9, p2277 

    Dementia with Lewy bodies (DLB) represents the second most frequent type of neurodegenerative dementia in the elderly. Although most patients have sporadic DLB, a limited number of DLB families have been described, suggesting that genetic factors may contribute to DLB pathogenesis. Here, we...

  • Dopamine transporter SPECT using fast kinetic ligands: 123I-FP-β-CIT versus 99mTc-TRODAT-1. Van Laere, K.; De Ceuninck, L.; Dom, R.; Van Den Eynden, J.; Vanbilloen, H.; Cleynhens, J.; Dupont, P.; Bormans, G.; Verbruggen, A.; Mortelmans, L. // European Journal of Nuclear Medicine & Molecular Imaging;2004, Vol. 31 Issue 8, p1119 

    A comparative study was carried out on two promising presynaptic dopamine transporter single-photon emission tomography (SPECT) radioligands with a fast pharmacokinetic profile, 123I-FP-β-CIT (FP) and 99mTc-TRODAT-1 (TR), in order to assess their differential diagnostic power in early...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics