Abnormal oesophageal motility in patients with chronic cough

Kastelik J A; Redington A E; Aziz I; Buckton G K; Smith C M; Dakkak M; Morice A H
August 2003
Thorax;Aug2003, Vol. 58 Issue 8, p699
Academic Journal
BACKGROUND: Although gastro-oesophageal reflux is a recognised cause of chronic cough, the role of oesophageal dysmotility is unknown. The aim of this study was to determine the prevalence of abnormal oesophageal motility in a selected group of patients with chronic cough. METHODS: Oesophageal manometry and 24 hour pH monitoring were performed in 43 patients with chronic cough, 34 of whom had symptoms suggestive of gastro-oesophageal reflux. Comparative manometric measurements were made in 21 healthy subjects. RESULTS: Nine patients with chronic cough had normal manometry and 24 hour pH. Of the remaining 34 patients, 11 (32%) had abnormal manometry alone, five (15%) had abnormal 24 hour pH monitoring alone, and in 18 (53%) both tests were abnormal. Only one patient in the control group had manometric abnormalities. CONCLUSIONS: These results point to a previously unrecognised high prevalence of abnormal oesophageal manometry in patients presenting with chronic cough. Oesophageal dysmotility may therefore be important in the pathogenesis of cough in these patients.


Related Articles

  • Chronic Cough: An Update. Iyer, Vivek N.; Lim, Kaiser G. // Mayo Clinic Proceedings;Oct2013, Vol. 88 Issue 10, p1115 

    Cough persisting beyond 8 weeks (ie, chronic cough) is one of the most common reasons for an outpatient visit. A protracted cough can negatively affect one's quality of life by causing anxiety, physical discomfort, social isolation, and personal embarrassment. Herein, the anatomy and physiology...

  • DECIPHERING THE CRYPTIC NATURE OF GERD-INDUCED COUGH. Johnson, David A. // American Journal of Gastroenterology;Sep1994, Vol. 89 Issue 9, p1594 

    The authors prospectively characterized 12 patients with chronic cough thought to due to gastroesophageal reflux. All patients underwent radiographic studies and ambulatory pH monitoring with dual probe analysis in the distal and proximal esophagus, as well as esophagoscopy and bronchoscopy....

  • Laryngopharyngeal Reflux. Karkos, Petros D.; Issing, Wolfgang; Reichel, Oliver; Hess, Marcus // International Journal of Otolaryngology;2012, p1 

    In this article, the authors discuss various articles on chronic cough, postnasal drip and gastroesophageal reflux published in this issue of the periodical.

  • Gastroesophageal Reflux Disease as a Cause of Cough. Walling, Anne D. // American Family Physician;8/1/1999, Vol. 60 Issue 2, p637 

    Stresses the increasing recognition of gastroesophageal reflux disease (GERD) as an etiology of persistent cough. Cases of chronic cough in nonsmoking adults that may be attributed to GERD; Potential causes of chronic cough; Mechanism of cough production in GERD; Signs and symptoms of GERD;...

  • How To Detect Patients with Hidden GERD. Field, Steven // Cortlandt Forum;12/20/2002, Vol. 15 Issue 12, p22 

    Discusses the symptoms and diagnosis of gastroesophageal reflux disease. Key issues of interest; Analysis of pertinent topics and relevant issues; Implications on medical care.

  • An objective study of acid reflux and cough in children using an ambulatory pHmetry-cough logger. Chang, A. B.; Connor, F. L.; Petsky, H. L.; Eastburn, M. M.; Lewindon, P. J.; Hall, C.; Wilson, S. J.; Katelaris, P. H. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;May2011, Vol. 96 Issue 5, p468 

    Objective There are no objective ambulatory studies on the temporal relationship between reflux and cough in children. Commercial pHmetry loggers have slow capture rates (0.25 Hz) that limit objective quantification of reflux and cough. The authors aimed to evaluate if there is a temporal...

  • New Meaning for the Term 'Hacking'. Phillips, Barbara A. // Internal Medicine Alert;5/15/2013, Vol. 35 Issue 9, p65 

    This meta-analysis did not convincingly demonstrate a positive effect of gastric acid-suppressing treatment in patients with chronic cough.

  • Chronic cough may be a sign of reflux.  // Pulse;10/20/2010, Vol. 70 Issue 31, p12 

    The article offers information on the study conducted by researchers from the University of Manchester on chronic cough, in which, results indicated that there are close relations between episodes of coughing and gastroesophageal reflux symptoms.

  • Chronic Unexplained Cough And Gastroesophageal Reflux Disease: A Quick Clinical Review. Makkar, Ravinder PS; Sachdev, Gopal KR // Internet Journal of Internal Medicine;2003, Vol. 4 Issue 1, p9 

    Chronic cough may be caused or triggered by gastroesophageal reflux disease (GERD), which is the third most common cause of chronic unexplained cough after bronchial asthma and postnasal drip. Many patients with unexplained cough have underlying GERD without the classic reflux symptoms making...


Read the Article


Sign out of this library

Other Topics