Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis
- Abnormal liver differentiation and excessive angiogenesis in mice lacking Runx3. Lee, Jong-Min; Lee, Dong-Joon; Bae, Suk-Chul; Jung, Han-Sung // Histochemistry & Cell Biology;May2013, Vol. 139 Issue 5, p751
Runt-related transcription factor 3 (Runx3) is essential for normal mouse development, and Runx3 knock-out (KO) mice (FVB strain), which die within 24 h after birth, show various organ defects, such as lung hyperplasia. For proper early liver development, angiogenesis and liver cell...
- Angiogenesis in chronic viral hepatitis. Kukla, Michał; Gabriel, Andrzej; Waluga, Marek; Buldak, Rafał; Mazur, Włodzimierz // Gastroenterologia Polska / Gastroenterology;2009, Vol. 16 Issue 4, p304
It is unresolved whether angiogenesis is merely a homeostatic mechanism aimed at ensuring an adequate oxygen supply or one that exerts an additional pathogenic role leading to liver tissue damage. The development of fibrosis and the accumulation of inflammatory cells which occur in viral...
- Biological activities of fibroblast growth factor-2 in the adult myocardium. Detillieux, Karen A.; Sheikh, Farah; Kardami, Elissavet; Cattini, Peter A. // Cardiovascular Research;Jan2003, Vol. 57 Issue 1, p8
Fibroblast growth factor-2 (FGF-2) is a potent regulator of many cellular functions and phenomena, including cell proliferation, differentiation, survival, adhesion, migration, motility and apoptosis, and processes such as limb formation, wound healing, tumorigenesis, angiogenesis,...
- Hereditary hemorrhagic telangiectasia: an update on transforming growth factor ï¿½ signaling in vasculogenesis and angiogenesis. van den Driesche, Sander; Mummery, Christine L.; Westermann, Cornelius J.J. // Cardiovascular Research;Apr2003, Vol. 58 Issue 1, p20
Hereditary hemorrhagic telangiectasia (HHT) is a vascular disorder in humans which has been mapped to two genes, endoglin and activin receptor-like kinase-1 (ALK-1) both of which mediate signaling by transforming growth factor ï¿½ ligands in vascular endothelial cells. Animal models have...
- Overexpression of endothelial NO synthase induces angiogenesis in a co-culture model. Babaei, Saeid; Stewart, Duncan J. // Cardiovascular Research;Jul2002, Vol. 55 Issue 1, p190
Objective: Angiogenesis is a complex multistep process that involves endothelial cell (EC) migration, proliferation and differentiation into vascular tubes. NO has been reported to be a downstream mediator in the angiogenic response to a variety of growth factors, but the mechanisms by...
- ERRATUM. // Nature Medicine;Mar2000, Vol. 6 Issue 3, p356
Presents an erratum for the article 'PR39, a peptide regulator of angiogenesis,' published in the March 2000 issue of 'Nature Medicine,' volume 6, number 3.
- Polymeric system for dual growth factor delivery. Richardson, Thomas P.; Peters, Martin C.; Ennett, Alessandra B.; Mooney, David J. // Nature Biotechnology;Nov2001, Vol. 19 Issue 11, p1029
The development of tissues and organs is typically driven by the action of a number of growth factors. However, efforts to regenerate tissues (e.g., bone, blood vessels) typically rely on the delivery of single factors, and this may partially explain the limited clinical utility of many current...
- Corrigendum: LRG1 promotes angiogenesis by modulating endothelial TGF-Î² signalling. Wang, Xiaomeng; Abraham, Sabu; McKenzie, Jenny A. G.; Jeffs, Natasha; Swire, Matthew; Tripathi, Vineeta B.; Luhmann, Ulrich F. O.; Lange, Clemens A. K.; Zhai, Zhenhua; Arthur, Helen M.; Bainbridge, James W. B.; Moss, Stephen E.; Greenwood, John // Nature;9/26/2013, Vol. 501 Issue 7468, p578
A correction to the article "LRG1 promotes angiogenesis by modulating endothelial TGF-Î² signalling" that was published in the 2013 issue of the periodical is presented.
- Platelet-derived endothelial cell growth factor in human colon cancer angiogenesis: Role of... Takahashi, Yutaka; Bucana, Corazon D. // JNCI: Journal of the National Cancer Institute;08/21/96, Vol. 88 Issue 16, p1146
Examines the role of platelet-derived endothelial cell growth factor in colon cancer angiogenesis and whether it is derived from the tumor or infiltrating cells. Immunohistochemical staining; Vessel counting; Northern blot analysis; Densitometric quantitation; Statistical analyses.