Topical capsaicin-a novel and effective treatment for idiopathic intractable pruritus ani: a randomised, placebo controlled, crossover study

Lysy J; Sistiery-Ittah M; Israelit Y; Shmueli A; Strauss-Liviatan N; Mindrul V; Keret D; Goldin E
September 2003
Gut;Sep2003, Vol. 52 Issue 9, p1323
Academic Journal
PURPOSE: Pruritus ani is a common and embarrassing proctological condition which can be very difficult to treat. We report the results of a double blind placebo controlled study of treatment with capsaicin. METHODS: Firstly, a pilot open study was carried out on five patients to establish which of two doses was the most acceptable by comparing effectiveness and side effects. Secondly, a double blind, placebo controlled, crossover study of topical capsaicin was performed. This study involved two four week treatment phases separated by a one week washout phase. Forty four patients were randomised to receive locally either active capsaicin (0.006%) or placebo (menthol 1%) ointment over a four week period (22 patients per group). After four weeks of treatment and a one week washout period, the placebo group began to receive capsaicin while the treated group received placebo (menthol 1%) for another four weeks. At the end of the controlled study, responders from both groups continued with capsaicin treatment in an open labelled manner. RESULTS: Thirty one of 44 patients experienced relief during capsaicin treatment periods and did not respond to menthol; all patients not responding to capsaicin also failed on menthol (p<0.0001). In 13 patients, treatment with capsaicin was unsuccessful: eight patients did not respond to capsaicin treatment, one responded equally to capsaicin and placebo, and four others dropped out because of side effects. During the follow up period (mean 10.9 (SD 5.8) months), 29 "responders" needed a mean application of capsaicin every day (1.6 (SD 1.2); range 0.5-7 days) to remain symptom free (or nearly symptom free). CONCLUSION: Capsaicin is a new, safe, and highly effective treatment for severe intractable idiopathic pruritus ani.


Related Articles

  • Topical capsaicin cream was effective for chronic idiopathic intractable pruritis ani. Lysy, J.; Sistiery-Ittah, M.; Israelit, Y. // Evidence Based Medicine;May/Jun2004, Vol. 9 Issue 3, p86 

    The article discusses effectiveness of Topical capsaicin cream for chronic idiopathic intractable pruritis ani. Patients who had chronic idiopathic anal itching for three months or more did not respond to the traditional treatment. A thin layer of perianal topical capsaicin cream, was applied...

  • One-Two Pruritus Punch. Schwanke, Jane // Dermatology Times;Nov2002, Vol. 23 Issue 11, p15 

    Reports on the effectiveness of a treatment for pruritus that combines topical use of capsaicin and naltrexone oral medication. Complete elimination of pruritus within 12 days; Importance of proper dosage and application of capsaicin; Experience of pruritic symptoms after discontinuation of...

  • Relief of Idiopathic Generalized Pruritus in Dialysis Patients Treated with Activated Oral Charcoal. Pederson, James A.; Matter, Billy J.; Czerwinski, Anthony W.; Llach, Francisco // Annals of Internal Medicine;Sep80, Vol. 93 Issue 3, p446 

    Presents information on a study which compared the effect of oral charcoal on idiopathic generalized pruritus in stable patients undergoing maintenance hemodialysis to that of placebo dextrose. Results of skin tests; Effect of charcoal and placebo treatment upon the skin lesions; Discussion on...

  • Determination of Capsaicin Induced Increase in Dermal Blood Flow Using Laser Doppler Flowmetry Technique. Khambam, Sunil Kumar Reddy; Rao Naidu, Madireddy Umamaheshwar; Rani, Pingali Usha; Rao, Takallapalli Ramesh Kumar // Pharmacology & Pharmacy;Jul2011, Vol. 2 Issue 3, p159 

    In the present study, we evaluated laser Doppler flowmetry technique using LDF100C (Biopac systems) by determining blood flow changes following acute application of capsaicin on 12 healthy human subjects. Capsaicin applied locally (topical application) at a dose of 0.075% produced significant...

  • Topical Capsaicin for the Relief of Chronic Pain. Walling, Anne D. // American Family Physician;2/1/2005, Vol. 71 Issue 3, p577 

    Discusses a research on the efficacy of topical capsaicin in relieving acute or chronic pain. Reference to a study by L. Mason et al., published in the April 24, 2004 issue of the "British Medical Journal"; Identification of criteria for inclusion in the meta-analysis; Comparison from placebo...

  • Topical Capsaicin May Not Help Relieve Itch Induced by Serotonin. Reiman, Patty // Dermatology Times;Jun2000, Vol. 21 Issue 6, p6 

    Presents the results of a study made by researcher Elke Weisshaar and colleagues on the ineffectivity of topical capsaicin for the relief of serotonin-induced itch. Role of serotonin in uremic and hepatic pruritis; Treatment of hemodialysis-related itch with capsaicin.

  • A curried cure and recalling childbirth. Gold, Lorna // GP: General Practitioner;9/1/2003, p52 

    This article focuses on several medical researches. A study has been related to the use of capsaicin in the treatment of idiopathic pruritus ani. Of 44 patients with pruritus ani, 31 responded to topical treatment with 0.006 per cent capsaicin ointment, whereas only one responded to the control...

  • "Detachment of the carinal hook following endobronchial intubation with a double lumen tube"  // BMC Anesthesiology;2011, Vol. 11 Issue 1, p20 

    The article focuses on the study of postherpetic neuralgia and its treatment with a capsaicin eight percent dermal patch NGX-4010 following pretreatment with lidocaine 2.5 percent and prilocaine 2.5 percent anesthetic cream. Patch application duration was used to assess tolerability and Numeric...

  • Intraoperative ventilation: incidence and risk factors for receiving large tidal volumes during general anesthesia.  // BMC Anesthesiology;2011, Vol. 11 Issue 1, p22 

    The article focuses on the study of postherpetic neuralgia and its treatment with a capsaicin eight percent dermal patch NGX-4010 following pretreatment with lidocaine 2.5 percent and prilocaine 2.5 percent anesthetic cream. Patch application duration was used to assess tolerability and Numeric...


Read the Article


Sign out of this library

Other Topics