TITLE

Keeping neuroendocrine cells in check: roles for TGFbeta, Smads, and menin?

AUTHOR(S)
Dockray G J
PUB. DATE
September 2003
SOURCE
Gut;Sep2003, Vol. 52 Issue 9, p1237
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
10631316

 

Related Articles

  • Autocrine growth inhibition by transforming growth factor beta-1 (TGFbeta-1) in human neuroendocrine tumour cells. Wimmel A; Wiedenmann B; Rosewicz S // Gut;Sep2003, Vol. 52 Issue 9, p1308 

    BACKGROUND: and aim: The role of transforming growth factor beta-1 (TGFbeta-1) in neuroendocrine tumour biology is currently unknown. We therefore examined the expression and biological significance of TGFbeta signalling components in neuroendocrine tumours (NETs) of the gastroenteropancreatic...

  • Smad4: gatekeeper gene in head and neck squamous cell carcinoma. Korc, Murray // Journal of Clinical Investigation;Nov2009, Vol. 119 Issue 11, p3208 

    Unchecked cell growth is a hallmark of cancer. During oncogenesis, cancerous cells become resistant to the TGF-beta signaling pathway that usually keeps cell growth in check. The role of a critical mediator of this pathway, Smad4, in head and neck squamous cell carcinoma (HNSCC) remains unclear....

  • Menin and bone metabolism. Kaji, Hiroshi // Journal of Bone & Mineral Metabolism;Jul2012, Vol. 30 Issue 4, p381 

    Menin, a product of the MEN1 gene, is related to the ontogeny of several cancers such as MEN1 and sporadic endocrine tumors, although it is considered to be a tumor suppressor. Many proteins interact with menin, and it is involved in various biological functions in several tissues. Menin plays...

  • Smad6 inhibits signalling by the TGF-Beta superfamily. Imamura, Takeshi; Takase, Masao // Nature;10/9/1997, Vol. 389 Issue 6651, p622 

    Discusses research which isolated the SMAD protein Smad6 in a mouse. SMAD proteins signalling mediators of TGF-Beta superfamily; Explanation of roles of particular SMAD proteins; Differences of Smad6 from other SMAD proteins; Smad6 and phosphorylation of other SMAD proteins; Positive and...

  • Gonadotropin releasing hormone analogue (GnRHa) alters the expression and activation of Smad in human endometrial epithelial and stromal cells. Xiaoping Luo; Jingxia Xu; Chegini, Nasser // Reproductive Biology & Endocrinology;2003, Vol. 1, p125 

    Gonadotropin releasing hormone analogues (GnRHa) are often used to regress endometriosis implants and prevent premature luteinizing hormone surges in women undergoing controlled ovarian stimulation. In addition to GnRH central action, the expression of GnRH and receptors in the endometrium...

  • Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome. Dilley, William G.; Kalyanaraman, Somasundaram; Verma, Sulekha; Cobb, J Perren; Laramie, Jason M.; Lairmore, Terry C. // Molecular Cancer;2005, Vol. 4, p9 

    Background: Multiple Endocrine Neoplasia type 1 (MEN1, OMIM 131100) is an autosomal dominant disorder characterized by endocrine tumors of the parathyroids, pancreatic islets and pituitary. The disease is caused by the functional loss of the tumor suppressor protein menin, coded by the MEN1...

  • Opposing BMP and EGF signalling pathways converge on the TGF-Beta family mediator Smad 1. Kretzschmar, Marcus; Doody, Jacqueline // Nature;10/9/1997, Vol. 389 Issue 6651, p618 

    Discusses research which reported that Smad 1, which mediates bone morphogenetic proteins (BMPs), is a target of mitogenic growth-factor signalling through epidermal growth factor and hepatocyte growth factor receptor protein tyrosine kinases (RTKs). Growth factor TGF-Beta and cell regulation;...

  • An anchor for activation. Ten Dijke, Peter; Heldin, Carl-Henrik // Nature;1/14/1999, Vol. 397 Issue 6715, p109 

    Discusses research which showed the first intracellular step in the transforming growth factor (TGF)-beta/Smad pathway. Mechanism for regulation of signal transduction; Role of anchor proteins; Role of downstream effectors called Smads; Research by Tsukazaki et al in `Cell'; Identification of...

  • Smad signalling in the ovary. Kaivo-oja, Noora; Jeffery, Luke A.; Ritvos, Olli; Mottershead, David G. // Reproductive Biology & Endocrinology;2006, Vol. 4, p21 

    It has now been a decade since the first discovery of the intracellular Smad proteins, the downstream signalling molecules of one of the most important growth factor families in the animal kingdom, the transforming growth factor beta (TGF-beta) superfamily. In the ovary, several TGF-beta...

  • TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Heldin, Carl-Henrik; Miyazono, Kohei // Nature;12/4/1997, Vol. 390 Issue 6659, p465 

    Presents research which studied the mechanisms by which transforming growth factor-beta (TGF-beta) signals from the cell membrane to the nucleus. Identification of SMAD family of signal transducer proteins; Phosphorylation of pathway-restricted SMADs; Identification of inhibitory SMADs that...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics