TITLE

Rapid effect of inhaled steroids on nocturnal worsening og asthma

AUTHOR(S)
Frezza, G.; Terra-Filho, J.; Martinez, J.A.B.; Vianna, E.O.
PUB. DATE
July 2003
SOURCE
Thorax;Jul2003, Vol. 58 Issue 7, p632
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Inhaled steroids are the most commonly used anti-inflammatory agents for asthma and are increasingly recognised as having a more rapid onset of action than was previously thought. We have investigated the effect of a single dose of inhaled steroid on nocturnal worsening of asthma. Methods: Ten patients with steroid naive moderate asthma and nocturnal asthma participated in a randomised, double blind, placebo controlled, crossover trial. Participants spent three nights in the laboratory, one week apart. On each night they underwent spirometric testing at 16.00 hours and received one of the three treatments (placebo, bedomethasone 1000 µg, or fluticasone 1000 µg) delivered by metered dose inhaler. Spirometric tests were repeated at 04.00 hours the following morning. Results: Following placebo administration the mean (SE) overnight fall in FEV[sub 1] was 0.65 (0.27) I compared with -0.02 (0.13) I following fluticasone (p = 0.019) and 0.23 (0.12) I following beclomethasone (p = 0.048 v placebo). Conclusion: A single dose of inhaled steroid (within the therapeutic range) reduced the fall in FEV[sub 1] in patients with nocturnal asthma when administered at 16.00 hours. Nocturnal worsening of asthma is a useful model for testing inhaled steroid activity in a single night study.
ACCESSION #
10595451

 

Related Articles

  • STEROID-RELATED RISKS. Coggins, Mark D. // Today's Geriatric Medicine;Jul/Aug2014, Vol. 7 Issue 4, p8 

    The article discusses the effects of glucocorticoids (GCs), or steroids as differentiated from muscle-building anabolic steroids. Topics include its anti-inflammatory properties, its uses in treating conditions such as asthma, autoimmune disorders and some types of cancer, and forms in which...

  • Pharmacotherapy -- first-line maintenance therapy.  // CMAJ: Canadian Medical Association Journal Supplement;9/1/2005, Vol. 173 Issue 6, pS28 

    Examines several studies concerning first-line maintenance therapy for asthma. Leukotriene receptor antagonists available in Canada; Results of trials which examined the efficacy of antagonists compared with placebo in the pediatric population; Efficacy of leukotriene receptor antagonists...

  • Molekularne mechanizmy opornoÅ›ci na glukokortykoidy w astmie oskrzelowej. PASTUSZAK-LEWANDOSKA, DOROTA; BRZEZIAŃSKA, EWA; GÓRSKI, PAWEŁ // Alergia Astma Immunologia;gru2012, Vol. 17 Issue 4, p180 

    Glucocorticoids (GCs) are the most potent anti-inflammatory agents, widely used in the therapy of chronic inflammatory diseases, including bronchial asthma. The phenomenon of steroid resistance, although relatively rare, is connected with serious burden for the patient, as well as with...

  • BRONCHIAL ASTHMA. -TREATMENT WITH INTACGLOBÍN (INTRAVENOUS GAMMAGLOBULIN). Noda, A.; Vidal, A.; Rodríguez, B. // Revista VacciMonitor (Vacunología y Temas Afines);Oct2002, Vol. 11 Issue 4, p1 

    Introduction. The bronchial Asthma is a chronic inflammatory disease, characterized by a hiper-reactivity of the airway to a wide range of stimuli whose symptomatology depends on diverse degrees of bronchial obstruction. The intravenous gamma globulin exerts a series of anti-inflammatory effects...

  • beclometasone dipropionate.  // Royal Society of Medicine: Medicines;2002, p100 

    The article presents information on beclometasone dipropionate, a corticosteroid which is used primarily as an anti-asthmatic treatment to prevent attacks and also as an $anti-inflammatory for severe skin inflammation (eg eczema and psoriasis) and for inflammatory conditions of the nasal mucosa...

  • Becodisks.  // Royal Society of Medicine: Medicines;2002, p100 

    The article presents information on becodisk, a proprietary, prescription-only preparation of the corticosteroid and anti-inflammatory beclometasone dipropionate. It can be used to prevent asthmatic attacks, and is available as a powder in discs for inhalation from a Diskhaler device.

  • Steroid naive eosinophilic asthma: anti-inflammatory effects of fluticasone and montelukast. Joyaram, L.; Pizzichini, E.; Lemière, C.; Man, S. F. P.; Cartier, A.; Hargreave, F. E.; Pizzichini, M. M. M. // Thorax;Feb2005, Vol. 60 Issue 2, p100 

    Background: Inhaled corticosteroids and leukotriene receptor antagonists reduce airway eosinophilia and have been used as first line anti-inflammatory therapy for mild persistent asthma. Methods: A multicentre, rondomised, placebo controlled, parallel group study was performed to compare the...

  • Simvastatin in the treatment of asthma: lack of steroid-sparing effect. Douglas C Cowan // Thorax;Oct2010, Vol. 65 Issue 10, p891 

    BACKGROUND: Statins have anti-inflammatory actions which in theory are potentially beneficial in asthma. Small trials have failed to show a significant benefit, but a systematic study to evaluate the steroid-sparing effect of statin treatment has not been carried out. METHODS: A randomised,...

  • Beclometasone Dipropionate/Formoterol in an HFA-Propelled Pressurised Metered-Dose Inhaler. Chung, K. F. // Drugs;2006, Vol. 66 Issue 11, p1485 

    The article reports on the combination therapy of inhaled corticosteroids and long-acting B2-agonist. The combination therapy of these two drugs became an established treatment for patients with symptomatic and moderately severe asthma. Examples of the combination of inhaled corticosteroids and...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics