TITLE

Expression of S100A12 (EN-RAGE) in cystic fibrosis

AUTHOR(S)
Foell, D.; Seeliger, S.; Vogl, T.; Koch, H.-G.; Maschek, H.; Harms, E.; Sorg, C.; Roth, J.
PUB. DATE
July 2003
SOURCE
Thorax;Jul2003, Vol. 58 Issue 7, p613
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Chronic airway inflammation and recurrent infections are a core phenomenon in cystic fibrosis (CF). Diagnosing acute infectious exacerbations is difficult in the presence of chronic inflammatory processes. S100A12 exhibits proinflammatory functions via interaction with the multiligand receptor for advanced glycation end products. Blocking this interaction inhibits inflammatory processes in mice. Methods: The expression of S100A12 in lung specimens of patients with end stage lung disease of CF was investigated, and S100A12 levels in the serum of patients with acute infectious exacerbations of CF were measured. Results: Immunohistochemical studies of CF lung biopsy specimens revealed a significant expression of S100A12 by infiltrating neutrophils. High S100A12 levels were found in the sputum of patients with CF, and serum levels of S100A12 during acute infectious exacerbations were significantly increased compared with healthy controls (median 225 ng/ml v 46 ng/ml). After treatment with intravenous antibiotics the mean S100A12 level decreased significantly. There was also a significant difference between S100A12 levels in patients with acute infectious exacerbations and 18 outpatients without exacerbations (median 225 ng/ml v 105 ng/ml). Conclusions: S100A12 is extensively expressed at local sites of inflammation in CF. It is a serum marker for acute infectious exacerbations. High local expression of S100A12 suggests that this protein has a proinflammatory role during airway inflammation and may serve as a novel target for anti-inflammatory treatments.
ACCESSION #
10595446

 

Related Articles

  • Myeloperoxidase Promoter Polymorphism -463G Is Associated With More Severe Clinical Expression of Cystic Fibrosis Pulmonary Disease. Reynolds, Wanda F.; Sermet-Gaudelus, Isabelle; Gausson, Val�rie; Feuillet, Marie-No�lle; Bonnefont, Jean-Paul; Lenoir, G�rard; Descamps-Latscha, B�atrice; Witko-Sarsat, V�ronique // Mediators of Inflammation;4/1/2006, Vol. 2006 Issue 2, p1 

    The severity of cystic fibrosis (CF) pulmonary disease is not directly related to CFTR genotype but depends upon several parameters, including neutrophil-dominated inflammation. Identification of agents modulating inflammation constitutes a relevant goal. Myeloperoxidase (MPO) is involved in...

  • Finally, mice with CF lung disease. Frizzell, Raymond A.; Pilewski, Joseph M. // Nature Medicine;May2004, Vol. 10 Issue 5, p452 

    Increasing sodium absorption by overexpressing the epithelial sodium channel in mouse airways results in mucus accumulation and inflammation, changes that occur in the lungs of individuals with cystic fibrosis. The development of lung disease in these mice should provide insights into a disease...

  • Correlation of forced oscillation technique in preschool children with cystic fibrosis with pulmonary inflammation. Brennan, S.; Hall, G. L.; Horak, F.; Moeller, A.; Pitrez, P. M. C.; Franzmann, A.; Turner, S.; De Klerk, N.; Franklin, P.; Winfield, K. R.; Balding, E.; Stick, S. M.; Sly, P. D. // Thorax;Feb2005, Vol. 60 Issue 2, p159 

    Background: Lung disease in cystic fibrosis (CF) is established in early childhood with recurrent bacterial infections and inflammation. Using spirometry, the effect of this early lung damage cannot be measured until a child is 6 years of age when some irreversible lung damage may already have...

  • Leukotriene Receptor Antagonists in Children with Cystic Fibrosis Lung Disease: Anti-Inflammatory and Clinical Effects. Schmitt-Grohé, Sabina; Zielen, Stefan // Pediatric Drugs;2005, Vol. 7 Issue 6, p353 

    Cystic fibrosis (CF) lung disease is characterized by chronic endobronchial infection resulting in progressive pulmonary destruction; this is a major cause of mortality and morbidity. Neutrophils are the primary effector cells responsible for the progressive deterioration of lung function....

  • State of the Art: Why do the lungs of patients with cystic fibrosis become infected and why can't they clear the infection? Chmiel, James F.; Davis, Pamela B. // Respiratory Research;2003, Vol. 4, p1 

    Cystic Fibrosis (CF) lung disease, which is characterized by airway obstruction, chronic bacterial infection, and an excessive inflammatory response, is responsible for most of the morbidity and mortality. Early in life, CF patients become infected with a limited spectrum of bacteria, especially...

  • MicroRNAs in inflammatory lung disease -- master regulators or target practice? Oglesby, Irene K.; McElvaney, Noel G.; Greene, Catherine M. // Respiratory Research;2010, Vol. 11, p148 

    MicroRNAs (miRNAs) have emerged as a class of regulatory RNAs with immense significance in numerous biological processes. When aberrantly expressed miRNAs have been shown to play a role in the pathogenesis of several disease states. Extensive research has explored miRNA involvement in the...

  • Multiple-breath inert gas washout and spirometry versus structural lung disease in cystic fibrosis. Gustafsson, P. M.; De Jong, P. A.; Tiddens, H. A. W. M.; Lindblad, A. // Thorax;Feb2008, Vol. 63 Issue 2, p129 

    Background: A sensitive and valid non-invasive marker of early cystic fibrosis (CF) lung disease is sought. The lung clearance index (LCI) from multiple-breath washout (MBW) is known to detect abnormal lung function more readily than spirometry in children and teenagers with CF, but...

  • Evolution of pulmonary inflammation and nutritional status in infants and young children with cystic fibrosis. Ranganathan, Sarath C.; Parsons, Faith; Gangell, Catherine; Brennan, Siobhan; Stick, Stephen M.; Sly, Peter D. // Thorax;May2011, Vol. 66 Issue 5, p408 

    INTRODUCTION: Improved nutrition is the major proven benefit of newborn screening programmes for cystic fibrosis (CF) and is associated with better clinical outcomes. It was hypothesised that early pulmonary inflammation and infection in infants with CF is associated with worse nutrition....

  • Reasons for heterogeneous change in LCI in children with cystic fibrosis after antibiotic treatment. Yammine, Sophie; Bigler, Anja; Casaulta, Carmen; Singer, Florian; Latzin, Philipp; Horsley, Alex // Thorax;Feb2014, Vol. 69 Issue 2, p183 

    A letter to the editor and a response from the author of the article is presented titled "Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation" in 2013 issue.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics