TITLE

Role of Hepatitis B Virus Genotypes in Chronic Hepatitis B Exacerbation

AUTHOR(S)
Man-Fung Yuen; Sablon, Erwin; Ka-Ho Wong, Danny; He-Jun Yuan; Chun-Yu Wong, Benjamin; On-On Chan, Annie; Ching-Lung Lai
PUB. DATE
August 2003
SOURCE
Clinical Infectious Diseases;8/15/2003, Vol. 37 Issue 4, p593
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Hepatitis B virus (HBV) genotypes and precore and core promoter mutations were determined in 318 patients with HBV. Patients infected with HBV genotype B had a higher median alanine aminotransferase level and bilirubin level and a lower median albumin level during exacerbations of disease, compared with patients infected with HBV genotype C (all P < .001). By logistic regression analysis, HBV genotype B infection (P = .014) and low albumin levels (P = .006) were independently associated with a higher risk of hepatic decompensation during severe exacerbations of disease. Patients infected with genotype B had a significantly higher mortality due to hepatic decompensation than did patients with genotype C (70% vs. 27.8%; P = .05).
ACCESSION #
10592564

 

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