TITLE

Prolonged survival in motor neuron disease: a descriptive study of the King's database 1990-2002

AUTHOR(S)
Turner, M.R.; Parton, M.J.; Shaw, C.E.; Leigh, P.N.; Al-Chalabi, A.
PUB. DATE
July 2003
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Jul2003, Vol. 74 Issue 7, p995
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Motor neuron disease is a clinically heterogeneous disease with significant differences in survival. The authors have characterised a subset of long term survivors seen in a tertiary clinic over a 12 year period in terms of clinical variables and demographics, comparing them with short term survivors and the remaining population. Thirty of 769 patients survived more than 10 years, corresponding to 4% of the total population. Significantly younger onset of disease symptoms and a predominance of pure upper motor neuron signs at presentation characterised the long term survivors, but factors traditionally regarded as being associated with poor prognosis were also well represented. For a few people with motor neuron disease there remains the hope, whatever the initial presentation, that their subsequent survival will be longer than expected.
ACCESSION #
10590546

 

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