TITLE

Olfactory deficits and sleep disturbances in Parkinson's disease: a case-control survey

AUTHOR(S)
Henderson, J.M.; Lu, Y.; Wang, S.; Cartwright, H.; Halliday, G.M.
PUB. DATE
July 2003
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Jul2003, Vol. 74 Issue 7, p956
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Olfactory and seep disturbances are common in Parkinson's disease, and may be early disease indicators. Objective: To obtain information about olfactory and sleep deficits preceding the onset of motor symptoms n Parkinson's disease. Subjects: 38 community dweling patients with Parkin- son's disease (73% response rate) and 32 age matched controls (60% response rate). Methods: Using a questionnaire survey, the frequencies, timing, and relations between olfactory and sleep disturbances, drug treatment, mood, and motor deficits in Parkinson's disease were compared with those in age matched controls. Reliability of information was validated by informant interview in 9% of the sample. Interdependency of factors was assessed using Fisher's fourfold table test, and differences between populations were analysed using χ² and unpaired t tests. Results: Microsmia was reported by 26 patients (68%) (and only one control), on average within a year of the diagnosis of Parkinson's disease. More patients than controls had excessive daytime somnolence (45% v 6%), restless legs (50% v 19%), and abnormal movements during seep (34% v 0%), which generally occurred three to five years after diagnosis and were independent of mood dis- orders and drug treatment. Conclusions: Many patients with Parkinson's disease have microsmia at the onset of motor deficits, but some sleep disorders are a subsequent occurrence.
ACCESSION #
10590531

 

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