MRI lesion volume heterogeneity in primary progressive MS in relation with axonal damage and brain atrophy

Pelletier, D.; Nelson, S.J.; Oh, J.; Antel, J.P.; Kita, M.; Zamvil, S.S.; Goodkin, D.E.
July 2003
Journal of Neurology, Neurosurgery & Psychiatry;Jul2003, Vol. 74 Issue 7, p950
Academic Journal
journal article
Objectives: To investigate whether axonal damage in primary progressive (PP) multiple sclerosis (MS), as measured by proton magnetic resonance spectroscopy (HMRS) imaging and brain atrophy, is a function of T2 weighted brain lesion volume.Methods: 34 PP MS patients were divided into two categories: low (<3 cm(3), n = 18) or high (>or=3 cm(3), n = 16) T2 lesion load (LL). An Index of Brain Atrophy (IBA) was calculated and HMRS metabolite ratios were derived from a central brain area centred at the corpus callosum.Results: Patient groups did not differ with regard to clinical characteristics and showed lower mean IBA and mean N-acetylaspartate:creatinine (NAA:Cr) ratios compared to healthy controls.Conclusion: PP patients with low and high brain T2LL have detectable brain atrophy and NAA:Cr reduction compared to healthy controls. In PP MS, T2 lesions alone are insufficient to explain the presence of brain atrophy and decrease in NAA:Cr.


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