TITLE

A highly efficient strategy for the synthesis of 3-substituted salicylic acids by either directed ortho-lithiation or halogen—metal exchange of substituted MOM protected phenols followed by carboxylation

AUTHOR(S)
Lau, Stephen YW; Keay, Brian A
PUB. DATE
November 2001
SOURCE
Canadian Journal of Chemistry;Nov2001, Vol. 79 Issue 11, p1541
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A highly efficient synthesis of various 3-substituted salicylic acids is described starting from inexpensive starting materials and requiring no special apparatus.Key words: salicylic acids, ortho-metalation, halogen–metal exchange, methoxymethyl group.On décrit une synthèse très efficace d'acides salicyliques substitués en position 3, à partir de produits peu dispendieux et ne requérant pas d'appareils spéciaux.Mots clés : acides salicyliques, ortho-métallation, échange halogène–métal, groupe méthoxyméthyle.[Traduit par la Rédaction]
ACCESSION #
10586696

 

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