TITLE

Incorporation of [sup 13] C glucose into nicotinamide in E. coli and in S. cerevisiae

AUTHOR(S)
Gupta, Ram Nath; Hemscheidt, Thomas; Sayer, Brian G; Spenser, Ian D
PUB. DATE
April 2001
SOURCE
Canadian Journal of Chemistry;Apr2001, Vol. 79 Issue 4, p418
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The mode of incorporation into nicotinamide of label from [sup 13] C-labeled samples of D-glucose, in Escherichia coli and Saccharomyces cerevisiae, was determined by means of [sup 13] C NMR spectroscopy. The results, which confirm and extend early studies with radioactive tracers, permit a definitive choice to be made between alternative biogenetic proposals.Key words: nicotinic acid, nicotinamide, biosynthesis, glucose incorporation, [sup 13] C NMR.Faisant appel � la spectroscopie RMN du [sup 13] C, on a d�termin� le mode d'incorporation du [sup 13] C d'�chantillons de D-glucose marqu� dans le nicotinamide d'Escherichia coli et de Saccharomyces cerevisiae. Les r�sultats, qui confirment et qui �tendent la port�e d'�tudes ant�rieures � l'aide de marqueurs radioactifs, permettent de faire un choix d�finitif entre les diverses propositions biog�n�tiques.Mots cl�s : acide nicotinique, nicotinamide, biosynth�se, incorporation du glucose, RMN du [sup 13] C.[Traduit par la R�daction]
ACCESSION #
10562275

 

Related Articles

  • Depending on Dose, the B Vitamin Niacin Doubles as Heart Drug.  // Environmental Nutrition;Apr2003, Vol. 26 Issue 4, p7 

    Focuses on the nutritional value of niacin, also called vitamin B3. Category as both a vitamin and a drug; Effect of niacin of helping produce energy in the cells of the body; Dosage options.

  • niacin.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1584 

    An encyclopedia entry for "niacin," which refers to a B vitamin existing in the forms of either nicotinic acid or nicotinamide, is presented.

  • Lonza Hikes Niacin Prices.  // Chemical Week;2/27/2002, Vol. 164 Issue 8, p45 

    Focuses on the plan of Lonza to increase the worldwide price of niacin and niacinamide feed additives as of February 27, 2002. Percentage of price increase; Price increase in October 2001; Reasons for the recent price increase.

  • Editorial. Witczak, Zbigniew J.; Priebe, Waldemar // Current Organic Chemistry;Aug2008, Vol. 12 Issue 12, p972 

    The article discusses various reports published within the issue including one about the utilization of functionalized carbohydrate synthons as universal templates to number of new analogs of isomeric monosaccharides and another on the occurrence, synthesis and biosynthesis of bacterial heptoses.

  • Pyridine metabolism in tea plants: salvage, conjugate formation and catabolism. Ashihara, Hiroshi; Deng, Wei-Wei // Journal of Plant Research;Nov2012, Vol. 125 Issue 6, p781 

    Pyridine compounds, including nicotinic acid and nicotinamide, are key metabolites of both the salvage pathway for NAD and the biosynthesis of related secondary compounds. We examined the in situ metabolic fate of [carbonyl-C]nicotinamide, [2-C]nicotinic acid and [carboxyl-C]nicotinic acid...

  • The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor. Kyle Holen; Leonard Saltz; Ellen Hollywood; Konrad Burk; Axel-Rainer Hanauske // Investigational New Drugs;Feb2008, Vol. 26 Issue 1, p45 

    Summary   Background FK866 is a potent inhibitor or NAD synthesis. This first-in-human study was performed to determine the maximum-tolerated dose, toxicity profile, and pharmacokinetics on a 96-h continuous infusion schedule. Materials and methods Twenty four patients with advanced solid...

  • Identification of α- d-glucose-1-phosphate cytidylyltransferase involved in Ebosin biosynthesis of Streptomyces sp. 139. Qi, Xiao-Qiang; Sun, Qing-Li; Bai, Li-Ping; Shan, Jun-Jie; Zhang, Yang; Zhang, Ren; Li, Yuan // Applied Microbiology & Biotechnology;May2009, Vol. 83 Issue 2, p361 

    Ebosin, a novel exopolysaccharide produced by Streptomyces sp. 139 has antagonist activity for IL-1R in vitro and remarkable anti-rheumatic arthritis activity in vivo. Its biosynthesis gene cluster ( ste) has been identified. In this study, gene ste17 was expressed in Escherichia coli BL21 and...

  • monosaccharide.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1489 

    A definition of the "monosaccharide," which pertains to a simple sugar that cannot be decomposed by hydrolysis like fructose and glucose, is presented.

  • Co-fermentation of a mixture of glucose and xylose to ethanol by Zymomonas mobilis and Pachysolen tannophilus. Nan Fu; Paul Peiris // World Journal of Microbiology & Biotechnology;Jul2008, Vol. 24 Issue 7, p1091 

    Abstract  This research was designed to maximize ethanol production from a glucose-xylose sugar mixture (simulating a sugar cane bagasse hydrolysate) by co-fermentation with Zymomonas mobilis and Pachysolen tannophilus. The volumetric ethanol productivity of Z. mobilis with 50 g...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics