TITLE

The tumour suppressor CYLD negatively regulates NF-?B signalling by deubiquitination

AUTHOR(S)
Kovalenko, Andrew; Chable-Bessia, Christine; Cantarella, Giuseppina; Isra&edigr;l, Alain; Wallach, David; Courtois, Gilles
PUB. DATE
August 2003
SOURCE
Nature;8/14/2003, Vol. 424 Issue 6950, p801
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
NF-?B transcription factors have key roles in inflammation, immune response, oncogenesis and protection against apoptosis. In most cells, these factors are kept inactive in the cytoplasm through association with I?B inhibitors. After stimulation by various reagents, I?B is phosphorylated by the I?B kinase (IKK) complex and degraded by the proteasome, allowing NF-?B to translocate to the nucleus and activate its target genes. Here we report that CYLD, a tumour suppressor that is mutated in familial cylindromatosis, interacts with NEMO, the regulatory subunit of IKK. CYLD also interacts directly with tumour-necrosis factor receptor (TNFR)-associated factor 2 (TRAF2), an adaptor molecule involved in signalling by members of the family of TNF/nerve growth factor receptors. CYLD has deubiquitinating activity that is directed towards non-K48-linked polyubiquitin chains, and negatively modulates TRAF-mediated activation of IKK, strengthening the notion that ubiquitination is involved in IKK activation by TRAFs and suggesting that CYLD functions in this process. Truncations of CYLD found in cylindromatosis result in reduced enzymatic activity, indicating a link between impaired deubiquitination of CYLD substrates and human pathophysiology.
ACCESSION #
10551138

 

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