Breast Sentinel Lymph Node Biopsy Using Radioisotope Injection: Is One-Day Bette Than Two-Day Protocol?

Chok, Siu-Ho; Chow, Louis W.C.; Wong, Kam-Ho; Cheng, Kam-Chau; Ho, Wai-Yin
April 2003
American Surgeon;
Sentinel lymph node (SLN) biopsy is an evolving treatment approach for patients with operable breast cancer. There have been a number of variations in the biopsy technique. One is the timing of radioisotope injection, which might have a significant influence on the radiation exposure of the personnel in the operating room. The present study aims to compare the one-day with the two-day protocol to see which one is associated with a lower radiation hazard while giving similar results. There were 60 patients recruited; half of them had the SLN biopsy 4 hours after the injection and the other half 24 hours later. Patient characteristics were comparable in both groups. The mean numbers of SLNs found per patient were 1.46 and 1.96 respectively. There was a statistically significant difference in the dosage of radioactivity present in the resected specimen between both groups of patients. However, there were still a number of confounding factors, so the proposed hypothesis of getting less radiation exposure to the medical personnel by using a two-day approach should be further investigated.


Related Articles

  • Clinical axillary recurrence after sentinel node biopsy in breast cancer: a follow-up study of 220 patients. Sanjuàn, A.; Vidal-Sicart, S.; Zanón, G.; Pahisa, J.; Velasco, M.; Fernández, P.L.; Santamaría, G.; Farrús, B.; Muñoz, M.; Albanell, J.; Pons, F.; Vanrell, J.A. // European Journal of Nuclear Medicine & Molecular Imaging;Aug2005, Vol. 32 Issue 8, p932 

    Purpose: The aim of this study was to evaluate the frequency of false-negative (FN) sentinel node procedures in patients with breast cancer and the subsequent clinical outcome in such patients. Methods: A total of 325 breast cancer patients underwent sentinel lymph node biopsy at our institution...

  • Comparison of blue dye and gamma probe guided sentinel lymph node biopsy techniques in breast cancer patients. Ugur, Omer; Bozkurt, M. Fani; Sayek, Iskender; Gedikoglu, Gokhan; Baykal, Atac; Hamaloglu, Erhan; Etikan, Ilker; Konan, Ali; Erbas, Belkis // Turkish Journal of Cancer;Apr2003, Vol. 33 Issue 2, p82 

    The introduction of sentinel lymph node (SLN) biopsy has brought an innovative approach to the staging of early breast cancer. Up to date two methods have been described: a blue dye-guided lymphatic mapping procedure and a radioactivity guided SLN biopsy technique using a handheld gamma probe....

  • Technical Advances in Sentinel Lymph Node Biopsy for Breast Cancer. Tuttle, Todd M. // American Surgeon;May2004, Vol. 70 Issue 5, p407 

    Technical advances in the past several years have simplified and improved sentinel lymph node (SLN) biopsy for breast cancer. The use of alternative injection sites (skin or subareolar) yields high SLN identification rates and may shorten the learning curve associated with standard peritumoral...

  • Minimal Involvement of Sentinel Lymph Node in Breast Carcinoma: Prevailing Concepts and Challenging Problems. Rivera, Michael; Merlin, Scott; Hoda, Rana S.; Gopalan, Anuradha; Hoda, Syed A. // International Journal of Surgical Pathology;Oct2004, Vol. 12 Issue 4, p301 

    Discusses the concepts and challenges in the sentinel lymph node biopsy in breast carcinoma. Standard of care status attained by the biopsy; Pathological interpretation and clinical consequences of minimally involved sentinel lymph nodes.

  • The Effect of Excisional Biopsy on the Accuracy of Sentinel Lymph Node Mapping in Early Stage Breast Cancer: Comparison with Core Needle Biopsy. FORGHANI, MOHAMMAD NASER; MEMAR, BAHRAM; JANGJOO, ALI; ZAKAVI, RASOUL; MEHRABIBAHAR, MOSTAFA; DABBAGH KAKHKI, VAHID REZA; KASHANI, IDA; HASHEMIAN, FARNAZ; SADEGHI, RAMIN // American Surgeon;Nov2010, Vol. 76 Issue 11, p1232 

    Despite the successful application of sentinel node mapping in breast cancer patients, its use in patients with a history of previous excisional biopsy of the breast tumors is a matter of controversy. In the present study we evaluated the accuracy of sentinel node biopsy in this group of...

  • Sentinel Lymph Node Biopsy in the Management of Breast Cancer. Kumar, R.; Bozkurt, M.F.; Zhuang, H.; Alavi, A. // Indian Journal of Cancer;Apr2003, Vol. 40 Issue 2, p60 

    Sentinel node localization is the second most important development in this century after conservative lumpectomy for the treatment of early breast cancer. The sentinel node mapping is a new multidisciplinary approach for staging of axilla in an accurate and less morbid way as compared to...

  • The Feasibility and Accuracy of the Sentinel Lymph Node Biopsy for Breast Carcinoma. Jaderborg, Jana M; Harrison, Paul B. // American Surgeon;Aug1999, Vol. 65 Issue 8, p699 

    As the procedure of sentinel lymph node biopsy for breast cancer becomes more widely available, the practicality of it in the hands of general surgeons should be assessed. This is a study of the accuracy and use of this procedure. A prospective study was conducted at two university-affiliated...

  • Practice patterns of lymph-node mapping and sentinel-node biopsy for breast cancer in British Columbia. Chua, Boon; Olivotto, Ivo A.; Donald, James C.; Hayashi, Allen H.; Davis, Noelle; Rusnak, Conrad H. // Canadian Journal of Surgery;Aug2003, Vol. 46 Issue 4, p273 

    Examines practice patterns for sentinel-node biopsy (SNB) for breast cancer in British Columbia. Techniques for the surgical, imaging and pathologic assessments of SNB; Training of surgeons; Immunohistochemical evaluation of the sentinel nodes.

  • Early Adoption and Disturbing Disparities in Sentinel Node Biopsy in Breast Cancer. Edge, Stephen B. // JNCI: Journal of the National Cancer Institute;4/2/2008, Vol. 100 Issue 7, p449 

    The article discusses a paper on the use of sentinel lymph node biopsy (SLNB) in breast cancer that is published within this issue.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics