TITLE

The Clinical Significance of an Isofunctioning Thyroid Nodule

AUTHOR(S)
Hedayati, Nasim; McHenry, Christopher R.
PUB. DATE
April 2003
SOURCE
American Surgeon;
SOURCE TYPE
DOC. TYPE
Article
ABSTRACT
The management of an "isofunctioning" thyroid nodule--defined by radioiodine uptake equivalent to normal thyroid tissue--is often a dilemma. Our goal was to determine the percentage of thyroid nodules that were isofunctioning and the frequency with which carcinoma occurred in an isofunctioning nodule. Patients referred for evaluation of a thyroid nodule from 1990 to 2002 were reviewed and those with an iodine-123 thyroid scintiscan were identified. Nodule size, serum thyrotropin, fine-needle aspiration biopsy, pathology, and follow-up were determined for patients with an isofunctioning, hypofunctioning, or hyperfunctioning thyroid nodule. Of the 562 patients with a thyroid nodule 273 (49%) had a thyroid scan. Nodules were hypofunctioning in 232 (85%), isofunctioning in 29 (11%), and hyperfunctioning in 12 (4%) patients. Mean nodule size and serum thyrotropin level were respectively 2.49 ± 0.23 cm and 1.73 ± 0.26 µIU/mL for isofunctioning, 2.47 ± 0.31 cm and 0.83 ± 0.21 µIU/mL for hyperfunctioning, and 3.94 ± 0.13 cm and 1.86 ± 0.28 µIU/mL for hypofunctioning nodules. Seventeen patients with an isofunctioning nodule underwent thyroidectomy and 12 patients were followed for a mean 27 months without an increase in nodule size. No patient with a hyperfunctioning nodule, six patients (21%) with an isofunctioning nodule, and 44 patients (19%) with a hypofunctioning nodule had a carcinoma. We conclude that the risk of malignancy in an isofunctioning nodule is similar to that of a hypofunctioning nodule and therefore the management should be based on routine fine-needle aspiration biopsy.
ACCESSION #
10544816

 

Related Articles

  • The Association of Benign and Malignant Ovarian Adenofibromas with Breast Cancer and Thyroid Disorders. Silva, Elvio G.; Tornos, Carmen; Malpica, Anais; Deavers, Michael T.; Tortolero-Luna, Guillermo; Gershenson, David M. // International Journal of Surgical Pathology;Jan2002, Vol. 10 Issue 1, p33 

    Examines the relationship of benign and malignant ovarian adenofibromas with breast cancer and thyroid disorders. Influences of the similar hormones of the organs; Link between the disorders and genetic changes; Differences between the clinical and pathological features of the patients with the...

  • A Taller-Than-Wide Shape in Thyroid Nodules in Transverse and Longitudinal Ultrasonographic Planes and the Prediction of Malignancy. Moon, Hee Jung; Kwak, Jin Young; Kim, Eun-Kyung; Kim, Min Jung // Thyroid;Nov2011, Vol. 21 Issue 11, p1249 

    Background: A 'taller-than-wide' shape is associated with thyroid malignancy, but taller-than-wide in which plane is most accurate is unclear. We determined in which ultrasonography (US) plane a taller-than-wide shape is most predictive of malignancy. Methods: A total of 471 thyroid nodules from...

  • goiter.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p972 

    An encyclopedia entry for "goiter" is presented. It refers to thyroid gland enlargement that may be caused by thyroiditis, benign thyroid nodules, malignancy, iodine deficiency or any condition that causes hyperfunction or hypofunction of the gland. Some of the types of goiter include aberrant...

  • Management of Thyroid nodules in adult patients. Chee Yean Eng; Quraishi, Muhammad S.; Bradley, Patrick J. // Head & Neck Oncology;2010, Vol. 2 Issue 1, p1 

    Thyroid nodule is a common presentation and requires a structured diagnostic approach to ascertain the risk of malignancy and determine appropriate management. This review article highlights the key points in the history and examination which can help with risk stratification. It also discussed...

  • Gene-expression assay successfully predicted benign disease in indeterminate thyroid nodules.  // Endocrine Today;Aug2012, Vol. 10 Issue 8, p18 

    The article discusses research into effectiveness of the Afirma Gene Expression Classifier from Veracyte in identifying benign cases in indeterminate thyroid nodules, conducted by Erik Alexander and colleagues, published in a 2012 issue of "New England Journal of Medicine."

  • Management of the solitary thyroid nodule. Wheeler, M. H. // Journal of the Royal Society of Medicine;Aug1988, Vol. 81 Issue 8, p437 

    The author reflects on topics related to the management of thyroid nodules. According to the author, it has been surveyed the thyroid nodules occurs commonly in ages between 30 to 59 years and 4.2% of a population of 5000. Furthermore, a higher occurrence might be expected in an iodine-deficient...

  • Lingual thyroid gland: Clinical evaluation and comprehensive management. Kalan, A.; Tariq, M. // ENT: Ear, Nose & Throat Journal;May1999, Vol. 78 Issue 5, p340 

    Presents information on a study which described a case of lingual thyroid gland and the management of such condition. Case background; Symptoms reported by the woman with a lump at the back of her throat; Clinical evaluation and management protocol for patient with lingual thyroid.

  • Lingual thyroid. Neinas, Frederick W.; Gorman, Colum A.; Devine, Kenneth D.; Woolner, Lewis B. // Annals of Internal Medicine;Aug73, Vol. 79 Issue 2, p205 

    Describes several cases of lingual thyroid. Complaints of patients with lingual abnormalities; Basis of the diagnosis of carcinoma; Factors which indicate a need for excisional biopsy.

  • Mucoepidermoid carcinoma of the thyroid gland arising from... Arezzo, Alberto; Patetta, Roberta; Ceppa, Paola; Borgonovo, Giacomo; Torre, Giancarlo; Mattioli, Francesco P. // American Surgeon;Apr1998, Vol. 64 Issue 4, p307 

    Presents information on a case of mucoepidermoid carcinoma of the thyroid gland. Etiology of the disease; Result of the pathological examination; Discussion on the occurrence of the disease.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics