TITLE

Niacin as a Component of Combination Therapy for Dyslipidemia

AUTHOR(S)
Miller, Michael
PUB. DATE
June 2003
SOURCE
Mayo Clinic Proceedings;Jun2003, Vol. 78 Issue 6, p735
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Dyslipidemia is one of the most important modifiable risk factors for coronary disease. Despite the availability of highly effective lipid-modifying agents, many patients still do not reach lipid targets established by national guidelines. Niacin has been known to be an effective treatment of dyslipidemia for almost half a century. Niacin substantially increases high-density lipoprotein cholesterol (HDLC) levels while lowering levels of low-density lipoprotein cholesterol (LDL-C), triglycerides, and lipoprotein(a). In addition, niacin converts small LDL particles into more buoyant, less atherogenic LDL particles. Combined with other agents, niacin offers an important treatment option for patients with dyslipidemia. In particular, niacin complements LDL-C-lowering drugs; it is the most effective agent available for increasing HDL-C levels while lowering levels of LDL-C and triglycerides and improving other lipid risk factors such as lipoprotein(a). Combining niacin with statins or bile acid sequestrant therapy is safe and effective for improving lipid levels and decreasing coronary risk. Differences in niacin formulations dictate tolerability profiles and should be considered when selecting niacin as part of lipid therapy. Furthermore, adverse effects on glucose and insulin sensitivity should be considered when selecting candidates for niacin therapy. Adding niacin to lipid-lowering regimens is a valuable option for physicians treating patients with dyslipidemia and should be considered in appropriate patients.
ACCESSION #
10544704

 

Related Articles

  • RE: “PRIOR TO USE OF ESTROGEN REPLACEMENT THERAPY, ARE USERS HEALTHIER THAN NONUSERS?”. Willett, Walter C. // American Journal of Epidemiology;1997, Vol. 146 Issue 3, p283 

    A letter to the editor is presented in response to the article "Prior to use of estrogen replacement therapy, are users healthier than nonusers?," by K.A. Matthews and colleagues in a previous issue.

  • THE AUTHORS REPLY. Matthews, Karen A.; Wing, Rena R.; Kuller, Lewis H.; Meilahn, Elaine N.; Plantinga, Pam // American Journal of Epidemiology;1997, Vol. 146 Issue 3, p283 

    A response is presented by Karen A. Matthews and colleagues to the comments of Walter C. Willett on their article "Prior to use of estrogen replacement therapy, are users healthier than nonusers?" in a previous issue.

  • RESEARCH REVIEWS. Chocolate Lowers Risk of Coronary Heart Disease: Review and Comments on the National Heart, Lung, and Blood Institute Family Heart Study. Schulman, Risa // HerbalGram;May-Jul2012, Issue 94, p38 

    No abstract available.

  • Statins bring long-term falls in non-CVD disease. Anekwe, Lilian // Pulse;9/7/2011, Vol. 71 Issue 28, p15 

    The article reports on the result of a study conducted by researchers in Great Britain, which shows that long-term intake of statins decreases the risk of non-fatal myocardial infarction and fatal coronary heart disease (CHD).

  • Batters up. Portyansky, Elena // Drug Topics;9/1/97, Vol. 141 Issue 17, p27 

    Focuses on the drug Niaspan, the extended-release form of niacin. Approval of Niaspan for prescription sales; Problems which the drug is designed to treat; Attributes of the drug.

  • Statin/niacin combination produces dramatic increase in HDL cholesterol.  // Formulary;May2000, Vol. 35 Issue 5, p445 

    Reports that a combination of statin and niacin increases high-density lipoprotein cholesterol. Clinical tests results; Risk factors; Potential place of Nicostatin in therapy.

  • Extended-Release Niacin for Type 2 Diabetes Dyslipidemia. Sadovsky, Richard // American Family Physician;11/15/2002, Vol. 66 Issue 10, p1980 

    Evaluates the safety and efficacy of low-dose extended-release niacin in managing dyslipidemia in patients with diabetes mellitus. Patients included in the study; Liver enzyme levels of the patients.

  • Enfuvirtide/niacin interaction.  // Reactions Weekly;1/22/2011, Issue 1335, p19 

    The article describes the case report of an interaction of enfuvirtide and niacin in a patient with HIV infection.

  • Implementing the new ATP III cholesterol guidellines.  // Patient Care;Nov2002, Vol. 36 Issue 13, p19 

    Presents guidelines for clinical cholesterol management recommended by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults, also known as Adult Treatment Panel (ATP) III, released in May 2001. ...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics