Numbers needed to treat derived from meta-analysis: a word of caution

July 2003
ACP Journal Club;Jul/Aug2003, Vol. 139 Issue 1, pA-15
Academic Journal
Comments on an editorial by Doctor Arthur Marx and Doctor Heiner Bucher in the March/April 2003 issue of 'ACP Journal Club' about meta-analysis. Baseline risk of included trials.


Related Articles

  • Meta-analysis of individual patient data from randomized trials: a review of methods used in practice. Simmonds, Mark C; Higgins, Julian PT; Stewart, Lesley A; Tierney, Jayne F; Clarke, Mike J; Thompson, Simon G // Clinical Trials;2005, Vol. 2 Issue 3, p209 

    Background Meta-analyses based on individual patient data (IPD) are regarded as the gold standard for systematic reviews. However, the methods used for analysing and presenting results from IPD meta-analyses have received little discussion. Methods We review 44 IPD meta-analyses published during...

  • Pharmacotherapy of Alzheimer Disease. Seow, Dennis; Gauthier, Serge // Canadian Journal of Psychiatry;Oct2007, Vol. 52 Issue 10, p620 

    Objective: To systematically review published clinical trials of the pharmacotherapy of Alzheimer disease (AD). Method: We searched MEDLINE for published English-language medical literature, using Alzheimer disease and treatment as key words. No other search engine was used. Our review focused...

  • Meta-Analysis Methods for Synthesizing Treatment Effects in Multisite Studies: Hierarchical Linear Modeling (HLM) Perspective. Kalaian, Sema A. // Practical Assessment, Research & Evaluation;2002-2003, Vol. 8, p1 

    A multisite study can be defined as the conduct of a research to study the effectiveness of similar or variations of the same interventions across multiple similar or distinct sites. These sites can involve multiple clusters of individuals, clinics, schools, classrooms, geographic locations,...

  • Meta-analyses versus randomised controlled trials in intensive care medicine. Brazzi, L.; Bertolini, G.; Minelli, C. // Intensive Care Medicine;Feb2000, Vol. 26 Issue 2, p239 

    Focuses on the comparison of meta-analysis with randomized controlled trials in intensive care medicine. Role of the tools in clinical research; Disadvantages of using meta-analysis in studies; Limitations in the knowledge of the experimental conditions.

  • Calcium channel blockers best against stroke risk. Baines, Emma // GP: General Practitioner;10/8/2004, p8 

    The article focuses on a review of existing trial data that states that Calcium channel blockers are more effective than other antihypertensives at reducing the risk of stroke. Researchers from Italy and Belgium carried out a meta-analysis of 13 trials comparing treatments for hypertension. The...

  • LESSONS LEARNED FROM THE TRENCHES OF METATRIANGULATION RESEARCH. Saunders, Carol S.; Jasperson, 'Jon; Butler, Brian S.; Carte, Traci A. // Communications of AIS;2003, Vol. 11, p245 

    In this paper we describe our application of a relatively untried research approach called metatriangulation. Metatriangulation is a three-phased, qualitative meta-analysis process that may be used to explore variations in the assumptions of alternative paradigms, gain insights into these...

  • Outcome selection bias in meta-analysis. Williamson, P. R.; Gamble, C.; Altman, D. G.; Hutton, J. L. // Statistical Methods in Medical Research;Oct2005, Vol. 14 Issue 5, p515 

    Publication bias has been previously identified as a threat to the validity of a meta-analysis. Recently, new evidence has documented an additional threat to validity, the selective reporting of trial outcomes within published studies. Several diseases have several possible measures of outcome....

  • Size Matters…Sometimes.  // Clinical Oncology Alert;Oct2007 Clinical Briefs in Primary, p20 

    The article discusses research being done on the use of meta-analysis in comparing results of similar clinical trials that employed large population size. It references a study by P.C. Gotzsche and colleagues published in the "Journal of the American Medical Association." It highlights the...

  • Meta-analyses in Cancer Clinical Trials: Principles and Pitfalls. Benson, J. R.; Saeb-Parsy, K. // World Journal of Surgery;Jul2006, Vol. 30 Issue 7, p1177 

    The article reports on the incorporation of meta-analyses in research strategy and clinical trials for the effective treatment of cancer and other diseases. Meta-analyses aid in revealing significant therapeutic effects through analysis and combination of several trials and research but on the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics