High Levels of Adenosine Deaminase in a Patient with Herpetic Encephalitis and Initial Negative PCR Results

López-Gómez, Manuel; López-Ruz, Miguel A.; Jiménez-Alonso, Juan
July 2003
Clinical Infectious Diseases;7/1/2003, Vol. 37 Issue 1, p147
Academic Journal
The finding of high levels of adenosine deaminase (ADA) in CSF samples may be an important diagnostic clue for tuberculosis meningitis. The determination of ADA levels in CSF samples now forms part of the routine diagnostic work-up for tuberculosis meningitis in many countries where tuberculosis is endemic. It has been reported that ADA levels of 110 IU⁄L in the CSF of patients with meningitis could be a strong indication of tuberculosis meningitis, although high levels of ADA have also been found associated with neurobrucellosis and pyogenic meningitis.


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