TITLE

Reevaluating Fluoroquinolone Breakpoints for Salmonella enterica Serotype Typhi and for Non-Typhi Salmonellae

AUTHOR(S)
Crump, John A.; Barrett, Timothy J.; Nelson, Jennifer T.; Angulo, Frederick J.
PUB. DATE
July 2003
SOURCE
Clinical Infectious Diseases;7/1/2003, Vol. 37 Issue 1, p75
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Salmonella enterica infections cause considerable morbidity and mortality worldwide. Antimicrobial therapy may be lifesaving for patients with extraintestinal infections with S. enterica serotype Typhi or non-Typhi salmonellae. Because antimicrobial resistance to several classes of traditional first-line drugs has emerged in the past several decades, the quinolone antimicrobial agents, particularly the fluoroquinolones, have become the drugs of choice. Recently, resistance to nalidixic acid has emerged among both Typhi and non-Typhi Salmonella serotypes. Such Salmonella isolates typically also have decreased susceptibility to fluoroquinolones, although minimum inhibitory concentrations of the fluoroquinolones usually are within the susceptible range of the interpretive criteria of the NCCLS. A growing body of clinical and microbiological evidence indicates that such nalidixic acid-resistant S. enterica infections also exhibit a decreased clinical response to fluoroquinolones. In this article, we recommend that laboratories test extraintestinal Salmonella isolates for nalidixic acid resistance, we recommend that short-course fluoroquinolone therapy be avoided for infection with nalidixic acid-resistant extraintestinal salmonellae, and we summarize existing data and data needs that would contribute to reevaluation of the current NCCLS fluoroquinolone breakpoints for salmonellae.
ACCESSION #
10364973

 

Related Articles

  • Increasing Quinolone Resistance in Salmonella enterica Serotype Enteritidis. M ø lbak, Kåre; Gerner-Smidt, Peter; Wegenert, Henrik C. // Emerging Infectious Diseases;May2002, Vol. 8 Issue 5, p514 

    Provides information on a study that monitored resistance to the drug quinolones in Salmonella enterica serotype enteritidis from human infections. Methodology of the study; Results and discussion; Conclusions.

  • Snapshot of Antimicrobial Stewardship in Australian Hospitals. Chen, Alex W. J.; Khumra, Sharmila; Eaton, Vaughn; Kong, David C. M. // Journal of Pharmacy Practice & Research;Mar2010, Vol. 40 Issue 1, p19 

    Background: The diminishing investment into the development of new antimicrobials is of significant global concern. This, coupled with the emergence of anti-infective drug resistance, highlights the need to both prolong and optimise the use of existing antimicrobials. Strategies or programs to...

  • European Surveillance of Antibiotic Consumption (ESAC) point prevalence survey 2008: paediatric antimicrobial prescribing in 32 hospitals of 21 European countries. Amadeo, Brice; Zarb, Peter; Muller, Arno; Drapier, Nico; Vankerckhoven, Vanessa; Rogues, Anne-Marie; Davey, Peter; Goossens, Herman // Journal of Antimicrobial Chemotherapy (JAC);Oct2010, Vol. 65 Issue 10, p2247 

    Background: Antimicrobials are the most common medicines prescribed to children, but very little is known about patterns of hospital paediatric antimicrobial prescribing. This study aimed at describing paediatric antimicrobial prescribing in European hospitals to identify targets for quality...

  • Failing to tackle drug-resistant superbugs will cost up to $100 trillion.  // Healthcare Purchasing News;Jan2015, Vol. 39 Issue 1, p18 

    The article discusses the Review on Antimicrobial Resistance study conducted by economist Jim O'Neill for British Prime Minister David Cameron to assess the global mortality and morbidity impact of superbug infection.

  • Possible Role of Curcumin as an Efflux Pump Inhibitor in Multi Drug Resistant Clinical Isolates of Pseudomonas aeruginosa. NEGI, NIDHI; PRAKASH, PRADYOT; GUPTA, MOHAN LAL; MOHAPATRA, TRIBHUBAN MOHAN // Journal of Clinical & Diagnostic Research;Oct2014, Vol. 8 Issue 10, p4 

    Introduction: Multidrug resistant non-fermenters are continuously increasing in hospital and ICU settings. One of the mechanisms of developing drug resistance is possession of efflux pump through which bacteria extrude antimicrobial agents and other toxic substances. If these efflux channels are...

  • Bacterial pericarditis and antimicrobial resistance at the Tehran Heart Center, Iran. Anvari, Maryam Sotoudeh; Kianinejad, Rezvan; Boroumand, Mohammad Ali; Arzhan, Soraya; Jalali, Arash // Journal of Infection in Developing Countries;Jul2015, Vol. 9 Issue 7, p780 

    Introduction: When bacterial pericarditis is suspected, urgent pericardial drainage combined with intravenous antibacterial therapy is mandatory to avert devastating, life-threatening complications. There have been scanty results on antimicrobial susceptibility of common causative microorganisms...

  • High Mortality from Blood Stream Infection in Addis Ababa, Ethiopia, Is Due to Antimicrobial Resistance. Seboxa, Teshale; Amogne, Wondwossen; Abebe, Workeabeba; Tsegaye, Tewodros; Azazh, Aklilu; Hailu, Workagegnehu; Fufa, Kebede; Grude, Nils; Henriksen, Thor-Henrik // PLoS ONE;12/15/2015, Vol. 10 Issue 12, p1 

    Background: Managing blood stream infection in Africa is hampered by lack of bacteriological support needed for antimicrobial stewardship, and background data needed for empirical treatment. A combined pro- and retrospective approach was used to overcome thresholds in clinical research in...

  • Applications of ozone therapy in dentistry. Gupta, Shiva; Deepa, D. // Journal of Oral Research & Review;Jul-Dec2016, Vol. 8 Issue 2, p86 

    Ozone is an allotropic form of oxygen, which is effectively used in the treatment of different diseases for more than 100 years. In the present era of increasing antibiotic resistance, ozone therapy is an alternative medical treatment that rationales to increase the amount of oxygen to the body...

  • CTX-M enzymes are the predominant extended-spectrum β-lactamases produced by Enterobacteriaceae in Ireland. Morris, Dearbháile; Boyle, Fiona; Buckley, Victoria; Li Xu; Hanahoe, Belinda; Hawkey, Peter; Cormican, Martin // Journal of Antimicrobial Chemotherapy (JAC);Oct2009, Vol. 64 Issue 4, p864 

    The article presents a study that deals with the predominance of CTX-M ß-lactamases among extended-spectrum ß-lactamase-producing Enterobacteriaceae in Ireland. Focal to the study was a nationwide survey of ESBL-PE collected throughout Ireland over an 11 year period. It highlighted the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics