Factors Associated with Hepatitis C Virus Infection in Injection and Noninjection Drug Users in Italy

Quaglio, Gianluca; Lugoboni, Fabio; Pajusco, Benedetta; Sarti, Maddalena; Talamini, Giorgio; Lechi, Alessandro; Mezzelani, Paolo; Jarlais, Don C. Des
July 2003
Clinical Infectious Diseases;7/1/2003, Vol. 37 Issue 1, p33
Academic Journal
We describe the prevalence of hepatitis C virus (HCV) infection among noninjection users of heroin in Italy and compare the prevalence of HCV infection among noninjection drug users (NIDUs) and injection drug users (IDUs). Multiple logistic regression analysis of data from NIDUs showed that hepatitis B virus (HBV) infection status was the only independent predictor of HCV seroprevalence. Among IDUs, the number of years of drug use and HBV and human immunodeficiency virus infection status were independent predictors of HCV seropositivity. We found an HCV infection prevalence of 20% among NIDUs. This rate was much lower than that for IDUs, who are 11 times more likely to have antibodies against HCV. The prevalence of HCV infection was much higher than that of HBV infection among the IDUs. In contrast, the prevalence of HBV infection was slightly higher than that of HCV infection among unvaccinated NIDUs. The prevalence of HCV infection among long-term IDUs approached true population saturation; among long-term NIDUs, however, it appeared to plateau at ∼40%. Additional research on HCV infection among NIDUs is needed to develop a strategic prevention program for this patient subgroup.


Related Articles

  • Vital Signs: Demographic and Substance Use Trends Among Heroin Users -- United States, 2002-2013. Jones, Christopher M.; Logan, Joseph; Gladden, R. Matthew; Bohm, Michele K. // MMWR: Morbidity & Mortality Weekly Report;7/10/2015, Vol. 64 Issue 26, p719 

    Background: Heroin use and overdose deaths have increased significantly in the United States. Assessing trends in heroin use among demographic and particular substance-using groups can inform prevention efforts. Methods: FDA and CDC analyzed data from the National Survey on Drug Use and Health...

  • Predictors and Prevention of Nonfatal Overdose Among Street-Recruited Injection Heroin Users in the San Francisco Bay Area, 1998-1999. Seal, Karen H.; Kral, Alex H.; Gee, Lauren; Moore, Lisa D.; Bluthenthal, Ricky N.; Lorvick, Jennifer; Edlin, Brian R. // American Journal of Public Health;Nov2001, Vol. 91 Issue 11, p1842 

    Objectives. This study sought to determine prevalence of and risk factors for nonfatal recent overdose among street-recruited injection heroin users. Methods. From August 1998 through July 1999, 1427 heroin injectors were recruited from 6 innercity neighborhoods in the San Francisco Bay Area,...

  • Explaining the Effectiveness of Heroin-assisted Treatment on Crime Reductions. Löbmann, Rebecca; Verthein, Uwe // Law & Human Behavior (Springer Science & Business Media B.V.);Feb2009, Vol. 33 Issue 1, p83 

    This study examines the relationship between heroin-assisted treatment versus methadone maintenance and the criminal activity of 1,015 individuals participating in a German model project. The main objective is to investigate how these treatments contribute to a decline of criminal behavior. The...

  • Heroin in Bratislava: The needle and the damage done. Reynolds, Matthew J.; Habsudova, Zuzana // Slovak Spectator;07/31/2000, Vol. 6 Issue 29, pI 

    Presents a heroin addiction case of an automobile mechanic in Slovakia. What motivated young people to use heroin; Average age of a Slovak heroin addict; Decline in the number of heroin addicts in Slovakia.

  • Heroin is back, with younger users. Schmidt, Laura // Addiction Letter;Nov94, Vol. 10 Issue 11, p1 

    Reports on the shift from a cocaine epidemic to a heroin and opioid epidemic in the United States. Increase in high-risk addictive practices; Population age of drug addicts; Impact on the treatment process of the emergence of a diverse population; Age of onset; Strength of the drug; Client's...

  • Hooked on Heroin.  // Scholastic Choices (Teacher's Edition);Apr2003, Vol. 18 Issue 7, pT3 

    Focuses on heroin addiction.

  • Health of heroin misusers in Germany drops. Karcher, Helmut L. // BMJ: British Medical Journal (International Edition);08/16/97, Vol. 315 Issue 7105, p387 

    Reports on a study indicating that the general health of heroin misusers in Germany has worsened. Study of misusers participating in detoxification program between 1989 and 1993 at the University of Hamburg; Increase in incidence of hepatitis B and hepatitis C among the patients; Rise in number...

  • Trends in Injection Drug Use Among Persons Entering Addiction Treatment--New Jersey, 1992-1999.  // MMWR: Morbidity & Mortality Weekly Report;5/18/2001, Vol. 50 Issue 19, p378 

    Summarizes an analysis of trends in injection drug use among persons admitted to New Jersey addiction treatment programs during 1992 to 1999. Decrease in the proportion of users who injected heroin, cocaine and both drugs from 1980 through the early 1990s; Comparison between the patterns of...

  • Rapid HCV test program identified many unreported infections.  // Infectious Disease News;May2014, Vol. 27 Issue 5, p41 

    The article reports on the success of a pilot program in Wisconsin that offers rapid hepatitis C virus testing to injection drug users in identifying significant number of infections that were previously unreported.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics