Opportunistic Mycelial Fungal Infections in Organ Transplant Recipients: Emerging Importance of Non-Aspergillus Mycelial Fungi

Hussain, Shahid; D. Alexander, Barbara; Munoz, Patricia; K. Avery, Robin; Houston, Sally; Pruett, Timothy; Jacobs, Richard; A. Dominguez, Edward; G. Tollemar, Jan; Baumgarten, Katherine; M. Yu, Chen; M. Wagener, Marilyn; Linden, Peter; Kusne, Shimon; Singh, Nina
July 2003
Clinical Infectious Diseases;7/15/2003, Vol. 37 Issue 2, p221
Academic Journal
To determine the spectrum and impact of mycelial fungal infections, particularly those due to non-Aspergillus molds, 53 liver and heart transplant recipients with invasive mycelial infections were prospectively identified in a multicenter study. Invasive mycelial infections were due to Aspergillus species in 69.8% of patients, to non-Aspergillus hyalohyphomycetes in 9.4%, to phaeohyphomycetes in 9.4%, to zygomycetes in 5.7%, and to other causes in 5.7%. Infections due to mycelial fungi other than Aspergillus species were significantly more likely to be associated with disseminated (P = .005) and central nervous system (P = .07) infection than were those due to Aspergillus species. Overall mortality at 90 days was 54.7%. The associated mortality rate was 100% for zygomycosis, 80% for non-Aspergillus hyalohyphomycosis, 54% for aspergillosis, and 20% for phaeo-hyphomycosis. Thus, non-Aspergillus molds have emerged as significant pathogens in organ transplant recipients. These molds are more likely to be associated with disseminated infections and to be associated with poorer outcomes than is aspergillosis.


Related Articles

  • Update on the Laboratory Diagnosis of Invasive Fungal Infections. Posteraro, Brunella; Torelli, Riccardo; De Carolis, Elena; Posteraro, Patrizia; Sanguinetti, Maurizio // Mediterranean Journal of Hematology & Infectious Diseases;2011, Vol. 3 Issue 1, p1 

    Recent advances in the management of patients with haematological malignancies and transplant recipients have paralleled an increase in the incidence of fungal diseases due to pathogenic genera such as Candida and Aspergillus and the emergence of less common genera including Fusarium and...

  • Clinical manifestations and management of cryptococcal infection. Subramanian, S.; Mathai, D. // Journal of Postgraduate Medicine;Oct-Dec2005 Supplement, Vol. 51, pS21 

    Cryptococcus neoformans is an important fungal pathogen causing invasive infection, especially of the central nervous system in this era of the HIV/AIDS epidemic. The choice of treatment depends on site(s) of infection and the patient's immune status. Use of appropriate antifungal agents...

  • Laboratory investigation of fungal infections of the central nervous system. Davis, John A.; Costello, Daniel J.; Venna, Nagagopal // Neurology India;Jul-Sep2007, Vol. 55 Issue 3, p233 

    While fungal infections of the central nervous system (CNS) are relatively rare, fungal pathogens are increasingly being recognized as an important etiology of CNS infections, particularly amongst the growing immunocompromized population. In this paper we aim to provide a practical approach to...

  • Cerebral and spinal cord involvement resulting from invasive aspergillosis. Guermazi, A.; Benchaib, N.; Zagdanski, A. M.; Hocqueloux, L.; Rili, M.; Molina, J. M.; de Kerviler, E. // European Radiology;Jan2002, Vol. 12 Issue 1, p147 

    Although central nervous system involvement in disseminated aspergillosis is known to occur in immunocompromised patients, particularly after bone marrow transplantation, localized involvement of the spinal cord is exceedingly rare. In this report we present and illustrate detailed imaging...

  • (1→ 3)-β-D-Glucan in Cerebrospinal Fluid as a Biomarker for Candida and Aspergillus Infections of the Central Nervous System in Pediatric Patients. Salvatore, Christine M.; Chen, Tempe K.; Toussi, Sima S.; DeLaMora, Patricia; Petraitiene, Ruta; Finkelman, Malcolm A.; Walsh, Thomas J. // Journal of the Pediatric Infectious Diseases Society;Sep2016, Vol. 5 Issue 3, p277 

    Background. Fungal infections of the central nervous system (FICNS) are important causes of morbidity and mortality among immunocompromised pediatric patients. Standard diagnostic modalities lack the sensitivity for detecting and therapeutically monitoring these life-threatening diseases....

  • Comparison of extracellular phospholipase activities in clinical and environmental Aspergillus fumigatus isolates. Birch, Mike; Denning, David W.; Robson, Geoffrey D. // Medical Mycology;Feb2004, Vol. 42 Issue 1, p81 

    Extracellular phospholipase production by environmental and clinical isolates of Aspergillus fumigatus collected from several centres world-wide were compared. All isolates produced extracellular phospholipases which included phospholipase C and a phospholipid acyl hydrolase (phospholipase A...

  • Disseminated Infection due to Saksenaea vasiformis Secondary to Cutaneous Mucormycosis. Gómez-Camarasa, Cristina; Rojo-Martín, María; Miranda-Casas, Consuelo; Alastruey-Izquierdo, Ana; Aliaga-Martínez, Luis; Labrador-Molina, José; Navarro-Marí, José // Mycopathologia;Feb2014, Vol. 177 Issue 1/2, p97 

    Mucormycosis is an uncommon opportunistic fungal infection caused by Zygomycetes. It usually affects immunocompromised, diabetic and trauma patients with infected wounds. We report a case of disseminated infection secondary to facial cutaneous mucormycosis caused by Saksenaea vasiformis in a...

  • CNS Aspergillosis: Recognition, Diagnosis and Management. Ruhnke, Markus; Kofla, Grzegorz; Otto, Kirsten; Schwartz, Stefan // CNS Drugs;2007, Vol. 21 Issue 8, p659 

    Early diagnosis of CNS aspergillosis requires a high degree of clinical suspicion, because there are no typical clinical symptoms or CSF findings. Clinical features are usually dramatic and tend to progress rapidly. Changes in mental status, hemiparesis and seizures are most common, but other...

  • Central nervous system aspergillosis in an immunocompetent patient. Köse, Şükran; Çavdar, Gülsün; Senger, Süheyla Serin; Akkoçlu, Gülgün // Journal of Infection in Developing Countries;Apr2011, Vol. 5 Issue 4, p313 

    Aspergillus sp. is a fungus that is very common in nature and may cause invasive disease with high mortality, especially in immunosuppressed patients. Here we present a case of central nervous system (CNS) aspergillosis in a previously healthy immunocompetent patient. A 23-year-old female was...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics