TITLE

An International Prospective Study of Pneumococcal Bacteremia: Correlation with In Vitro Resistance, Antibiotics Administered, and Clinical Outcome

AUTHOR(S)
L. Yu, Victor; C. C. Chiou, Christine; Feldman, Charles; Ortqvist, Ake; Rello, Jordi; J. Morris, Arthur; M. Baddour, Larry; M. Luna, Carlos; R. Snydman, David; Lp, Margaret; Wen Chien Ko; Bernadete F. Chedid, M.; Andremont, Antoine; P. Klugman, Keith
PUB. DATE
July 2003
SOURCE
Clinical Infectious Diseases;7/15/2003, Vol. 37 Issue 2, p230
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We performed a prospective, international, observational study of 844 hospitalized patients with blood cultures positive for Streptococcus pneumoniae. Fifteen percent of isolates had in vitro intermediate susceptibility to penicillin (minimum inhibitory concentration [MIC], 0.12-1 mg/mL), and 9.6% of isolates were resistant (MIC, 32 mg/mL). Age, severity of illness, and underlying disease with immunosuppression were significantly associated with mortality; penicillin resistance was not a risk factor for mortality. The impact of concordant antibiotic therapy (i.e., receipt of a single antibiotic with in vitro activity against S. pneumoniae) versus discordant therapy (inactive in vitro) on mortality was assessed at 14 days. Discordant therapy with penicillins, cefotaxime, and ceftriaxone (but not cefuroxime) did not result in a higher mortality rate. Similarly, time required fordefervescence and frequency of suppurative complications were not associated with concordance of b-lactam antibiotic therapy. b-Lactam antibiotics should still be useful for treatment of pneumococcal infections that do not involve cere-brospinal fluid, regardless of in vitro susceptibility, as determined by current NCCLS breakpoints.
ACCESSION #
10360957

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics