Dramatic post-cardiotomy outcome, due to severe anaphylactic reaction to protamine

Panos, A.; Orrit, X.; Chevalley, C.; Kalangos, A.
August 2003
European Journal of Cardio-Thoracic Surgery;Aug2003, Vol. 24 Issue 2, p325
Academic Journal
Immunologic reactions to protamine sulfate during cardiac surgery are very rare. The frequency and outcome of such adverse reactions is unclear. We report a case of lethal anaphylactic reaction to protamine that occurred in a non-diabetic patient following the uneventful replacement of the ascending aorta. We also briefly review the mechanisms of this adverse reaction and emit some considerations on the management of this situation.


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