The Effects of Celecoxib or Naproxen on Blood Pressure in Pediatric Patients with Juvenile Idiopathic Arthritis

Falkner, B.; Berger, M.; Brown, P. Bhadra; Iorga, D.; Nickeson, R. W.; Zemel, L.
January 2015
Clinical Medicine Insights: Pediatrics;2015, Issue 9, p55
Academic Journal
BACKGROUND: Selective and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) are indicated for the treatment of juvenile idiopathic arthritis (JIA). However, the effect of NSAIDs on blood pressure (BP) in children has not been rigorously examined. METHODS: In this randomized, double-blind, multicenter, active-controlled, 6-week trial, the safety and efficacy of celecoxib (50 mg twice daily [bid] or 100 mg bid) or naproxen (7.5 mg/kg bid) was evaluated in patients aged 2-17 years with JIA. RESULTS: The least squares (LS) mean difference (celecoxib - naproxen) in change from baseline to week 6/final visit in systolic BP was 1.10 (90% confidence interval, -0.56, 2.76). No significant LS mean differences in diastolic BP relative to baseline were reported. Treatment-emergent adverse events occurred in 48% of patients in each treatment group. CONCLUSION: Both celecoxib and naproxen had no impact on BP, and both treatments had comparable safety profiles. Celecoxib, or naproxen, could be seen as suitable treatment options for pediatric patients with JIA.


Related Articles

  • Celebrex versus magnesium sulfate to prevent premature labor. Salarieh, N.; Tabasi, Z.; Forozanfard, F.; Mahdian, M.; Mousavi, G. A. // Feyz Journal of Kashan University of Medical Sciences;2014, Vol. 18 Issue 1, p23 

    Background: Preterm labor is the leading cause of newborn deaths and a major public health challenge. The aim of this study was to compare the effect of celebrex and magnesium sulfate in the prevention of preterm labor. Materials and Methods: In this double-blind clinical trial, 100 patients...

  • Efficacy of celecoxib for pain management after arthroscopic surgery of hip: a prospective randomized placebo-controlled study. Zhang, Zhenxiang; Zhu, Wei; Zhu, Lixian; Du, Yaqing // European Journal of Orthopaedic Surgery & Traumatology;Aug2014, Vol. 24 Issue 6, p919 

    The present work was conducted to examine whether celecoxib, a selective COX-2 inhibitor, 200 mg administered 1 h preoperatively to patients undergoing arthroscopic hip surgery reduces postoperative pain. Fifty-three patients undergoing arthroscopic hip surgery under spinal anesthesia were...

  • Kardiovaskuläres Risiko von nicht-steroidalen Antirheumatika. Hermann, M. // Praxis (16618157);10/17/2012, Vol. 101 Issue 20, p1309 

    Classical non-steroidal anti-inflammatory drugs (NSAID) and new selective inhibitors of cyclooxygenase-2(Cox-2 inhibitors) have been successfully used for several decades in the treatment of patients with chronic pain. In addition of their well known adverse gastro-intestinal effects, these...

  • A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with ... Conaghan, Philip G.; Dickson, John; Bolten, Wolfgang; Cevc, Gregor; Rother, Matthias // Rheumatology;Jul2013, Vol. 52 Issue 7, p1303 

    Objective. To assess the efficacy and safety of 12-week treatment with ketoprofen in ultradeformable phospholipid vesicles in patients with OA knee pain and to compare the efficacy with that of ketoprofen-free vehicle and celecoxib.Methods. A multicentre, double-blind controlled study in which...

  • Naproxen Versus Ibuprofen in Pain Control after Periodontal Surgery: a Randomized Crossover Double-blind Clinical Trial. Aghasizadeh, Ershad; Mozaffari, Pegah Mosannen; Zargarpoor, Rosa; Vazirinegad, Reza; Rajaee, Sara; Namee, Majedeh; Amirchaghmaghi, Maryam // Australian Journal of Basic & Applied Sciences;2011, Vol. 5 Issue 9, p321 

    Objective: The purpose of this study was to compare analgesic efficacy of two none-steroidal anti-inflammatory drugs( NSAIDS),ibuprofen and naproxen in the management of post operative pain and swelling after periodontal surgery. Design: this study used a double-blind cross-over design with the...

  • Adverse Reaction Research.  // Reactions Weekly;12/6/2008, Issue 1231, p3 

    A conference paper about COX-2 inhibitors in subjects for whom blood pressure (BP) data were available is presented. It states that compared with placebo, the risk of developing new hypertension was increased with COX-2 inhibitors and this was driven largely by the increased risk associated with...

  • Dexketoprofen/tramadol: randomised double-blind trial and confirmation of empirical theory of combination analgesics in acute pain. Moore, R.; Gay-Escoda, C.; Figueiredo, R.; Tóth-Bagi, Z.; Dietrich, T.; Milleri, S.; Torres-Lagares, D.; Hill, C.; García-García, A.; Coulthard, P.; Wojtowicz, A.; Matenko, D.; Peñarrocha-Diago, M.; Cuadripani, S.; Pizà-Vallespir, B.; Guerrero-Bayón, C.; Bertolotti, M.; Contini, M.; Scartoni, S.; Nizzardo, A. // Journal of Headache & Pain;6/1/2015, Vol. 16 Issue 1, p1 

    Background: Combination analgesics are effective in acute pain, and a theoretical framework predicts efficacy for combinations. The combination of dexketoprofen and tramadol is untested, but predicted to be highly effective. Methods: This was a randomised, double-blind, double-dummy,...

  • Comparative study of the clinical efficacy of the selective cyclooxygenase-2 inhibitor celecoxib compared with loxoprofen in patients with frozen shoulder. Ohta, Satoru; Komai, Osamu; Hanakawa, Hiroyoshi // Modern Rheumatology;Jan2014, Vol. 24 Issue 1, p144 

    Background This is a randomized comparative study of the efficacy of celecoxib and loxoprofen in patients with frozen shoulder (scapulohumeral periarthritis). Methods Patients with frozen shoulder who presented with pain as the symptom were divided at random into a celecoxib treatment group (100...

  • Cardiovascular Effects of NSAIDs. SHERVE, KAITYANN; GERARD, CHRISTOPHER J.; NEHER, JON O.; ST. ANNA, LEILANI // American Family Physician;8/15/2014, Vol. 90 Issue 4, p256A 

    The article discusses cardiovascular outcomes associated with non-steroidal anti-inflammatory drug (NSAID) use. Topics explored include the results of a study which investigated the impact of aspirin on individuals with hypertension, highlights of randomized controlled trials (RCT) which involve...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics