TITLE

The importance of correction of anemia with erythropoietin and intravenous iron in severe resistant congestive heart failure

AUTHOR(S)
Wexler, Dov; Silverberg, Don; Sheps, David; Iaina, Adrian
PUB. DATE
June 2003
SOURCE
European Journal of Heart Failure. Supplements;Jun2003, Vol. 2 Issue 2, p225
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
About one third to one half of patients with heart failure are anemic, in that they have a hemoglobin level of less than 12 g/dL. Anemia is more common and more severe as the clinical status of CHF worsens. In addition, anemia is associated with a higher mortality and higher rate of hospitalization, as well as with signs of malnutrition. In anemic CHF patients who are resistant to maximally tolerated CHF medications and who remain very symptomatic, both uncontrolled studies of a combination of subcutaneous erythropoietin (EPO) and IV ferric sucrose have reported a correction of the anemia. This correction has been associated with an improvement in NYHA functional status, left ventricular ejection fraction, and a marked reduction in the doses of diuretic needed and in the frequency and duration of hospitalizations. Renal function, which had been steadily falling before the correction of the anemia, was also stabilized. Other controlled studies have also found that anemia correction with EPO increased oxygen utilization during maximal exercise, exercise endurance and quality to life. The anemia is probably due mainly to a combination of renal failure and excessive cytokines, both of which interfere with EPO production and utilization. If confirmed by larger studies, correction of anemia with the EPO-IV iron combination may become a useful adjuvant to the treatment of CHF.
ACCESSION #
10320185

 

Related Articles

  • Anemia in Chronic Heart Failure - Clinical and Prognostic Significance. Karhausen, T.; Anker, Stefan D.; Doehner, W. // Current Medicinal Chemistry - Cardiovascular & Hematological Age;Oct2005, Vol. 3 Issue 4, p297 

    Anemia is a common finding in chronic heart failure (CHF). Anemia develops due to CHF, but is also known to cause heart failure. Patients with CHF are limited by exercise capacity and fatigue. Low hemoglobin concentration can account for both and may substantially contribute to the symptoms of...

  • Anaemia and renal dysfunction in chronic heart failure. van der Meer, Peter; van Veldhuisen, Dirk J. // Heart;Nov2009, Vol. 92 Issue 21, p18 

    The article focuses on the associative roles of renal disorder and anaemia to chronic heart disease. Study shows that impaired renal function can lead to anaemia which is a manifestation that a patient suffers from chronic heart failure. Moreover, excessive increase of haemoglobin in anaemic...

  • Anaemia and renal dysfunction are independently associated with BNP and NT-proBNP levels in patients with heart failure. Hogenhuis, Jochem; Voors, Adriaan A.; Jaarsma, Tiny; Hoes, Arno W.; Hillege, Hans L.; Kragten, Johannes A.; van Veldhuisen, Dirk J. // European Journal of Heart Failure;Aug2007, Vol. 9 Issue 8, p787 

    Abstract: Background: Anaemia may affect B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) levels, but this has not been well described in heart failure (HF) patients without the exclusion of patients with renal dysfunction. Aims: To study the influence of both anaemia and renal...

  • Anemia is a new complication in Fabry disease: data from the Fabry Outcome Survey. Kleinert, Julia; Dehout, François; Schwarting, Andreas; de Lorenzo, Abelardo García; Ricci, Roberta; Kampmann, Christoph; Beck, Michael; Ramaswami, Uma; Linhart, Ales; Gal, Andreas; Houge, Gunnar; Widmer, Urs; Mehta, Atul; Sunder-Plassmann, Gere; Dehout, François; de Lorenzo, Abelardo García // Kidney International;May2005, Vol. 67 Issue 5, p1955 

    Background: The prevalence and causes of anemia among patients with Fabry disease are unknown.Methods: In a cross-sectional study we examined hemoglobin concentrations of patients with Fabry disease using a large international database, the Fabry Outcome Survey (FOS),...

  • Anemia treatment in chronic kidney disease accompanied by diabetes mellitus or congestive heart failure. Fishbane, Steven; Miyawaki, Nobuyuki // Kidney International;Feb2010, Vol. 77 Issue 3, p175 

    Anemia is common in chronic kidney disease (CKD). The CHOIR study found increased risk of a composite cardiovascular outcome when anemia was treated with epoetin-alfa to a target hemoglobin level of 13.5 as compared with 11.3 g/dl. Whether this increase applies to all patient subgroups equally...

  • ANEMIC SYNDROME IN PATIENTS WITH ISCHEMIC HEART DISEASE AND CHRONIC HEART FAILURE. Kaluta, T. Yu.; Suvorova, S. A.; Shvarts, Y. G. // Saratov Journal of Medical Scientific Research / Saratovskii Nau;Oct-Dec2011, Vol. 7 Issue 4, p831 

    Anemic syndrome of different severity often accompanies ischemic heart disease (IHD) and chronic heart failure (CHF). Anemia has association with unfavorable prognosis in patients with all forms of CVD — acute and chronic. In this article the authors summarize a literature review of...

  • Effect of angiotensin converting enzyme inhibitors and angiotensin receptor blockers on hemoglobin levels. Ajmal, Adnan; Gessert, Charles E.; Johnson, Brian P.; Renier, Colleen M.; Palcher, Jeanette A. // BMC Research Notes;2013, Vol. 6 Issue 1, p1 

    Background Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are widely used in the management of congestive heart failure (CHF), diabetes mellitus (DM) and hypertension (HTN). Use of these agents is reported to cause anemia. Methods We examined the...

  • Anemia, heart failure linked.  // Geriatrics;Oct2005, Vol. 60 Issue 10, p11 

    Discusses research being done on the link between anemia and heart failure in older people. Reference to a study published in the 2005 issue of the journal "Circulation"; Decline in the level of hemoglobin among patients; Percentage of increase in risk of death and complications due to anemia...

  • Iron supplementation in the cardiorenal anaemia syndrome: a global metabolic approach. Pasini, Evasio; Dioguardi, Francesco Saverio // European Journal of Heart Failure;Dec2012, Vol. 14 Issue 12, p1429 

    No abstract available.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics