TITLE

Effect of anaemia on left ventricular hypertrophy in end-stage renal disease

AUTHOR(S)
Locatelli, Francesco; Pozzoni, Pietro; Del Vecchio, Lucia; Tentori, Francesca
PUB. DATE
June 2003
SOURCE
European Journal of Heart Failure. Supplements;Jun2003, Vol. 2 Issue 2, p207
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Cardiovascular disease (CVD) is highly prevalent among end-stage renal disease (ESRD) patients and is the main reason for their high mortality and morbidity rates. The large proportion of patients starting renal replacement therapy who also have CVD, suggests that pathogenetic factors leading to cardiac dysfunction begin in the early stages of chronic kidney disease (CKD). Anaemia may be an important pathogenetic factor responsible for cardiovascular abnormalities, in particular left ventricular hypertrophy (LVH), which significantly worsens the prognosis of CKD patients. This would account for the association between anaemia and both hospitalisation and mortality rates in such patients and leads to the expectation that correction of anaemia will improve cardiovascular status and long-term prognosis. A partial regression of LVH after a partial correction of anaemia has been observed in several studies, but it is still unclear whether normalizing haemoglobin concentrations produces additional cardiac advantages. Indeed, no significant differences between partial and complete correction of anaemia in inducing regression of established LVH have been demonstrated so far, but further investigation is needed. Furthermore, normalization of anaemia improves quality of life and physical function of selected categories of patients. Also keeping in mind the potential risks of haemoglobin normalization in haemodialysis patients with severe heart disease and grafts, individualising the target haemoglobin concentration to the characteristics of the patients is probably one of the winning strategies in the modern management of renal anaemia.
ACCESSION #
10320181

 

Related Articles

  • Anemia and Cardiovascular Risk in People with Diabetes and Chronic Kidney Disease: An Update. MCFARLANE, SAMY I. // Current Medical Literature: Diabetes;2008, Vol. 25 Issue 2, p41 

    The article examines the role of diabetes and chronic kidney disease (CKD) in increasing the risk for anemia and cardiovascular disease. Studies revealed the prevalence of anemia in the diabetic population such as the third National Health and Nutrition Examination survey (NHANES III). Among the...

  • Treatment of Anemia in Chronic Kidney Disease � Strategies Based on Evidence. Marsden, Philip A. // New England Journal of Medicine;11/19/2009, Vol. 361 Issue 21, p2089 

    The author discusses the use of the Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT) as a treatment for patients suffering from anemia with chronic kidney disease. He states that TREAT is effective in decreasing the risk of stroke which will outweigh the potential benefits of...

  • Normalization of Hemoglobin Level in Patients with Chronic Kidney Disease and Anemia. Dr�eke, Tilman B.; Locatelli, Francesco; Clyne, Naomi; Eckardt, Kai-Uwe; Macdougall, Iain C.; Tsakiris, Dimitrios; Burger, Hans-Ulrich; Scherhag, Armin // New England Journal of Medicine;11/16/2006, Vol. 355 Issue 20, p2071 

    Background: Whether correction of anemia in patients with stage 3 or 4 chronic kidney disease improves cardiovascular outcomes is not established. Methods: We randomly assigned 603 patients with an estimated glomerular filtration rate (GFR) of 15.0 to 35.0 ml per minute per 1.73 m2 of...

  • Anaemia among patients with heart failure and preserved or reduced ejection fraction: results from the SENIORS study. von Haehling, Stephan; van Veldhuisen, Dirk J.; Roughton, Michael; Babalis, Daphne; de Boer, Rudolf A.; Coats, Andrew J.S.; Manzano, Luis; Flather, Marcus; Anker, Stefan D. // European Journal of Heart Failure;Jun2011, Vol. 13 Issue 6, p656 

    Aims Anaemia is a co-morbidity frequently seen in patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF). Its presence carries adverse prognostic effects. The effects of anaemia have not been extensively investigated in patients with preserved or only mildly...

  • Anaemia as a Risk Factor for Cardiovascular Disease in Patients with Chronic Kidney Disease. Ephraim, Richard K. D.; Owiredu, William K. B. A.; Laing, Edwin F.; Amidu, Nafiu; Eghan Jnr, Benjamin A.; Ahenkorah, Linda // Journal of Medical Sciences;2008, Vol. 8 Issue 8, p707 

    This study evaluated whether anaemia poses a cardiovascular risk and whether the risk is modified by the presence of chionic kidney disease (CKD). Anaemia was defined as haemoglobin concentration ≤ 11.0 for both males and females. The study population included 50 individuals with various...

  • Risk - Complications and Comorbidities.  // Current Medical Literature: Diabetes;2010, Vol. 27 Issue 4, p140 

    The article discusses various studies related to diabetes complications and comorbidities. A study examined the association between anemia and cardiovascular disease in diabetes patients. One study found that the prevalence of testosterone deficiency was higher in men with diabetes. Another...

  • Pathogenesis and therapeutic implications of cardiorenal syndrome. Nitta, Kosaku // Clinical & Experimental Nephrology;Apr2011, Vol. 15 Issue 2, p187 

    Chronic kidney disease (CKD) is now widely accepted as a risk factor for cardiovascular disease and mortality. Heart failure patients with CKD have a worse prognosis. The heart and kidneys act in tandem to regulate blood pressure, vascular tone, diuresis, natriuresis, intravascular volume...

  • Chronic Kidney Disease Itself Is a Causal Risk Factor for Stroke beyond Traditional Cardiovascular Risk Factors: A Nationwide Cohort Study in Taiwan. Yi-Chun Chen; Yu-Chieh Su; Ching-Chih Lee; Yung-Sung Huang; Shang-Jyh Hwang // PLoS ONE;Apr2012, Vol. 7 Issue 4, p1 

    Background: Cardiovascular disease (CVD) is a leading cause of mortality and morbidity in patients with chronic kidney disease (CKD). In Taiwan, CVD is dominated by strokes but there is no robust evidence for a causal relationship between CKD and stroke. This study aimed to explore such causal...

  • Metabolic Risk Factors and Markers of Cardiovascular and Renal Damage in Overweight Subjects. Bigazzi, Roberto; Bianchi, Stefano; Batini, Valentina; Guzzo, Daniela; Campese, Vito M. // American Journal of Hypertension;Apr2006, Vol. 19 Issue 4, p426 

    Background: The prevalence of overweight and obesity in the United States has dramatically increased. Obesity clusters with a variety of hemodynamic and metabolic disturbances that increase the risk of cardiovascular disease. In this study we evaluated whether overweight subjects with...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics