Brucella melitensis Biovar 1 and Brucella abortus S19 Vaccine Strain Infections in Milkers Working at Cattle Farms in the Khartoum Area, Sudan

Osman, Amira E. F.; Hassan, Abdullahi N.; Ali, Ali E.; Abdoel, Theresia H.; Smits, Henk L.
May 2015
PLoS ONE;May2015, Vol. 10 Issue 5, p1
Academic Journal
Background: Human brucellosis is a preventable zoonoses that may become persistent, causing, if left untreated, severe localized disease. Occupational exposure to infected animals or animal products and consumption of fresh contaminated dairy are main risk factors. Methods: One hundred farmworkers employed at two cattle farms one in Khartoum North and one in Omdurman were screened for the presence of specific antibodies and seropositive workers were invited to donate a blood sample for blood culture. Molecular typing was used to characterize Brucella isolates. Results: Ten percent of farmworkers tested seropositive and while Brucella melitensis biovar 1 was isolated from the blood of three individuals, an isolate identical to the B. abortus S19 vaccine strain was isolated from a fourth person. All four bacteremic individuals were employed as milkers and did not have obvious disease. Conclusions: The isolation of the highly infectious pathogen B. melitensis from seropositive workers is consistent with the notion that the pathogen may persist in the blood without causing overt disease. While vaccination with strain S19 is essential for the control of bovine brucellosis the vaccine strain may be transmitted to the human population and protective measures remain important to prevent exposure also in view of the presence of B. melitensis. To create awareness for this potentially severe disease more information on the prevalence of the pathogen in different risk groups and in livestock in the Sudan is needed.


Related Articles

  • Brucella melitensis hepatitis: the absence of granulomas. Young, Edward J.; Young, E J // Annals of Internal Medicine;Sep79, Vol. 91 Issue 3, p414 

    Presents information on a study which evaluated the different histologic picture that characterizes hepatic involvement in infection due to Brucella melitensis. Major histologic finding in the liver of animals and humans infected with Brucella abortus; Basic differences in the pathogenesis of...

  • Brucellosis as a cause of acute febrile illness in Egypt Jennings, Gregory J.; Hajjeh, Rana A.; Girgis, Fouad Y.; Fadeel, Moustafa A.; Maksoud, Mohamed A.; Wasfy, Momtaz O.; Sayed, Nasr El; Srikantiah, Padmini; Luby, Stephen P.; Earhart, Kenneth; Mahoney, Francis J. // Transactions of the Royal Society of Tropical Medicine & Hygiene;Jul2007, Vol. 101 Issue 7, p707 

    Summary: To develop better estimates of brucellosis incidence, we conducted population-based surveillance for acute febrile illness (AFI) in Fayoum governorate (population 2347249), Egypt during two summer periods (2002 and 2003). All hospitals and a representative sample of community healthcare...

  • Obtaining Required Data via Delphi Expert Opinion Surveys and Target Groups Surveys for Calculation of Financial Losses Resulted from Brucellosis and Cost-Benefit Analysis of Alternative Brucellosis Control Strategies in Turkey. CAN, Mehmet Ferit; YALÇIN, Cengiz // Kafkas Universitesi Veteriner Fakultesi Dergisi;2011, Vol. 17 Issue 4, p601 

    This study aimed obtaining the data via Delphi Expert Opinion Surveys (DEOS) and Targeted Group Surveys (TGS) required for calculation of financial losses caused by Brucella abortus and Brucella melitensis in infected animals and humans and also required for performing cost-benefit analysis for...

  • Brucellosis: England and Wales.  // British Medical Journal (Clinical Research Edition);11/28/1981, Vol. 283 Issue 6304, p1477 

    Reports the decline of the number of patients affected with Brucella abortus in Great Britain. Difference between B. abortus and B. melitensis; Ratio of men to women infected with brucellosis; Importance of effective milk pasteurization on disease prevention.

  • Comparison of Heat Shock Response in Brucella abortus and Brucella melitensis. Amirmozafari, N.; Ghazi, F.; Mostafazadeh, A.; Mostafaie, A.; Rajabnia, R. // Pakistan Journal of Biological Sciences;2008, Vol. 11 Issue 2, p188 

    Heat shock protein (hsp) is highly conserved, that serves a wide range of function in protein folding and transport. It protect front various type of stress including heat shocks. However, it is well known that the virulence of B. melitensis is more than B. abortus, but there is not any strong...

  • Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy. Hamer, Isabelle; Goffin, Emeline; De Bolle, Xavier; Letesson, Jean-Jacques; Jadot, Michel // BMC Microbiology;2014, Vol. 14 Issue 1, p1 

    Background Several intracellular bacterial pathogens have evolved subtle strategies to subvert vesicular trafficking pathways of their host cells to avoid killing and to replicate inside the cells. Brucellae are Gram-negative facultative intracellular bacteria that are responsible for...

  • Sustained and differential antibody responses to virulence proteins of Brucella melitensis during acute and chronic infections in human brucellosis. Xu, J.; Qiu, Y.; Cui, M.; Ke, Y.; Zhen, Q.; Yuan, X.; Yu, Y.; Du, X.; Yuan, J.; Song, H.; Wang, Z.; Gao, G.; Yu, S.; Wang, Y.; Huang, L.; Chen, Z. // European Journal of Clinical Microbiology & Infectious Diseases;Mar2013, Vol. 32 Issue 3, p437 

    Brucellosis is an important zoonotic disease caused primarily by the bacterial pathogens Brucella melitensis and B. abortus. The pathogens cause debilitating febrile illness that can progress into a long-lasting disease with severe complications in humans. Understanding the mechanisms by which...

  • Antigenic, Immunologic and Genetic Characterization of Rough Strains B.abortus RB51, B.melitensis B115 and B.melitensis B18. Adone, Rosanna; Muscillo, Michele; Rosa, Giuseppina La; Francia, Massimiliano; Tarantino, Michela // PLoS ONE;2011, Vol. 6 Issue 10, p1 

    The lipopolysaccharide (LPS) is considered the major virulent factor in Brucella spp. Several genes have been identified involved in the synthesis of the three LPS components: lipid A, core and O-PS. Usually, Brucella strains devoid of O-PS (rough mutants) are less virulent than the wild type...

  • Infection of cattle in Kenya with Brucella abortus biovar 3 and Brucella melitensis biovar 1 genotypes. Muendo, Esther; Mbatha, Peter; Macharia, Joseph; Abdoel, Theresia; Janszen, Paul; Pastoor, Rob; Smits, Henk // Tropical Animal Health & Production;Jan2012, Vol. 44 Issue 1, p17 

    Brucella melitensis biovar 1 was isolated from bovine milk samples from a herd in central Kenya, and Brucella abortus biovar 3 was isolated from aborted fetus materials and vaginal discharge fluids from cattle in central and eastern provinces of Kenya. All infections including those with B....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics