Holographic optical coherence imaging of tumor spheroids

Yu, P.; Mustata, M.; Turek, J. J.; French, P. M. W.; Melloch, M. R.; Nolte, D. D.
July 2003
Applied Physics Letters;7/21/2003, Vol. 83 Issue 3, p575
Academic Journal
We present depth-resolved coherence-domain images of living tissue using a dynamic holographic semiconductor film. An AlGaAs photorefractive quantum-well device is used in an adaptive interferometer that records coherent backscattered (image-bearing) light from inside rat osteogenic sarcoma tumor spheroids up to 1 mm in diameter in vitro. The data consist of sequential holographic image frames at successive depths through the tumor represented as a visual video "fly-through." The images from the tumor spheroids reveal heterogeneous structures presumably caused by necrosis and microcalcifications characteristic of human tumors in their early avascular growth.


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