Physical Mechanisms of the Therapeutic Effect of Ultrasound (A Review)

Bailey, M. R.; Khokhlova, V. A.; Sapozhnikov, O. A.; Kargl, S. G.; Crum, L. A.
July 2003
Acoustical Physics;Jul2003, Vol. 49 Issue 4, p369
Academic Journal
Therapeutic ultrasound is an emerging field with many medical applications. High intensity focused ultrasound (HIFU) provides the ability to localize the deposition of acoustic energy within the body, which can cause tissue necrosis and hemostasis. Similarly, shock waves from a lithotripter penetrate the body to comminute kidney stones, and transcutaneous ultrasound enhances the transport of chemotherapy agents. New medical applications have required advances in transducer design and advances in numerical and experimental studies of the interaction of sound with biological tissues and fluids. The primary physical mechanism in HIFU is the conversion of acoustic energy into heat, which is often enhanced by nonlinear acoustic propagation and nonlinear scattering from bubbles. Other mechanical effects from ultrasound appear to stimulate an immune response, and bubble dynamics play an important role in lithotripsy and ultrasound-enhanced drug delivery. A dramatic shift to understand and exploit these nonlinear and mechanical mechanisms has occurred over the last few years. Specific challenges remain, such as treatment protocol planning and real-time treatment monitoring. An improved understanding of the physical mechanisms is essential to meet these challenges and to further advance therapeutic ultrasound. © 2003 MAIK “Nauka / Interperiodica”.


Related Articles

  • Comparison of mechanisms involved in image enhancement of Tissue Harmonic Imaging. Cleveland, Robin O.; Jing, Yuan // AIP Conference Proceedings;2006, Vol. 838 Issue 1, p263 

    Processes that have been suggested as responsible for the improved imaging in Tissue Harmonic Imaging (THI) include: 1) reduced sensitivity to reverberation, 2) reduced sensitivity to aberration, and 3) reduction in the amplitude of diffraction side lobes. A three-dimensional model of the...

  • Medical diagnostic ultrasound. Everbach, E. Carr // Physics Today;Mar2007, Vol. 60 Issue 3, p44 

    The article discusses the history and applications of medical diagnostic ultrasound. Biomedical ultrasound technologies evolved from the military use of sonar. Ultrasound scanners use piezoelectric crystals, usually lead zirconate titanate. Other topics discussed include the Doppler effect,...

  • Nonlinear Acoustics in Biomedical Ultrasound. Cleveland, Robin O. // AIP Conference Proceedings;2015, Vol. 1685 Issue 1, p1 

    Ultrasound is widely used to image inside the body; it is also used therapeutically to treat certain medical conditions. In both imaging and therapy applications the amplitudes employed in biomedical ultrasound are often high enough that nonlinear acoustic effects are present in the propagation:...

  • Pulsed Sounding of Cracks with the Use of the Modulation of Ultrasound by Vibrations. Kazakov, V. V.; Sutin, A. M. // Acoustical Physics;May2001, Vol. 47 Issue 3, p308 

    The possibility of using the effect of the modulation of ultrasound by vibrations due to the presence of cracks for the nonlinear acoustic detection of cracks is demonstrated. The method is based on a pulsed ultrasonic sounding with gating the received signal and simultaneously exciting...

  • Wave Processes in Media with Hysteretic Nonlinearity: Part 2. Nazarov, V. E.; Radostin, A. V.; Ostrovsky, L. A.; Soustova, I. A. // Acoustical Physics;Jul2003, Vol. 49 Issue 4, p444 

    Nonlinear processes caused by the propagation of low-frequency and high-frequency acoustic pulses in an unbounded medium and the propagation of continuous waves in a ring resonator are theoretically studied on the basis of two hysteretic equations of state for media with imperfect elasticity....

  • Parametric Reversal of Nonlinear Acoustic Waves. Brysev, A. P.; Mikhalevich, V. G.; Strel�tsov, V. N. // JETP Letters;6/10/2002, Vol. 75 Issue 11, p543 

    A mechanism of parametric reversal of the ultrasonic field from a quasi-monochromatic radiator situated in a nonlinear acoustic medium is proposed and analyzed. The mechanism is based on the phonon�plasmon interaction in semiconductors with a high concentration of electron traps, when a...

  • Nonexistence of Travelling Wave Solutions to Nonelliptic Nonlinear Schr�dinger Equations. Ghidaglia, J.M.; Saut, J.C. // Journal of Nonlinear Science;1996, Vol. 6 Issue 2, p139 

    By deriving Pohojaev-type identities we prove that nonelliptic nonlinear Schr�dinger equations do not admit localized travelling wave solutions. Similarly, we prove that the Davey-Stewartson hyperbolic-elliptic systems do not support travelling wave solutions except for a specific range of...

  • Effect of precipitate coherency strains on acoustic harmonic generation. Cantrell, John H.; Yost, William T. // Journal of Applied Physics;4/1/1997, Vol. 81 Issue 7, p2957 

    Investigates the effect of precipitate coherency strains on nonlinear acoustic harmonic generation. Acoustic nonlinearity with initial stress; Precipitate-matrix coherency strains; Variation of nonlinearity parameters from coherency strains; Application of model to aluminum alloy 2024 aging.

  • Electromagnetic Waves Generated by Opposite Acoustic Waves. Kolmakov, I. A. // Technical Physics Letters;Jan2001, Vol. 27 Issue 1, p67 

    An acoustic wave of a combined frequency (formed upon the superposition of the opposite acoustic waves of close frequencies) from a moving source generates electromagnetic waves of the same frequency with the amplitude increasing in the longitudinal direction. The problem is solved for the first...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics