Clinical features of Non-Hodgkins lymphoma presenting with acute liver failure: a report of five cases and review of published experience

Lettieri, Christopher J.; Berg, Benjamin W.
July 2003
American Journal of Gastroenterology;Jul2003, Vol. 98 Issue 7, p1641
Academic Journal
Hematological malignancies frequently affect the liver, but typically do not result in hepatic dysfunction and rarely present with advanced hepatic involvement. We report five patients who presented with advanced hepatic involvement and were found to have a high-grade lymphoma infiltrating the liver. Despite early diagnosis and initiation of therapy, all five patients deteriorated rapidly and died shortly after the onset of liver failure. Several similar cases have been reported. They share common clinical features, including hepatomegaly, lactic acidosis, and death shortly after the onset of symptoms. Non-Hodgkins lymphoma is a common malignancy, which is increasing in incidence. Non-Hodgkins lymphoma is not commonly entertained as an etiology of advanced liver failure and is likely underrecognized. In cases of acute advanced liver failure without an apparent etiology, especially if associated with hepatomegaly and lactic acidosis, lymphoma should be considered because of its poor prognosis and potential for treatment if recognized early. Liver biopsy is an invaluable tool that provides an early diagnosis while excluding other potential etiologies for acute advanced liver failure.


Related Articles

  • Primary Perinephric Lymphoma. Joshi, Pankaj M.; Date, Jaydeep; Shivde, S. R.; Rakesh, Jamkhindikar; Singh, Joshita; Raja, Langer // Internet Journal of Surgery;2010, Vol. 24 Issue 1, p1 

    The differential diagnosis of masses in the perinephric space and the peripelvic space of the renal hilum would include tumor, fluid, inflammation, or various proliferative diseases. More broadly, abnormal tissue at the periphery of the kidney may be subcapsular or perinephric in origin, and...

  • Acute Liver Failure due to Non-Hodgkin's Lymphoma. Saló, J.; Nomdedeu, B.; Bruguera, M.; Ordi, J.; Ginès, P.; Castells, A.; Vilella, A.; Rodés, J. // American Journal of Gastroenterology;May1993, Vol. 88 Issue 5, p774 

    Acute hepatic failure secondary to involvement of the liver by hematologic malignancies is a very uncommon condition, and usually has a fatal prognosis. We describe the case of a woman who developed acute hepatic failure due to infiltration by a non-Hodgkin's lymphoma 18 yr after the initial...

  • Color Doppler sonography and angioscintigraphy in hepatic Hodgkin's lymphoma. Stojković, Mirjana V.; Artiko, Vera M.; Radoman, Irena B.; Knežević, Slavko J.; Lukić, Snezana M.; Kerkez, Mirko D.; Lekić, Nebojsa S.; Antić, Andrija A.; Žuvela, Marinko M.; Ranković, Vitomir I.; Petrović, Milorad N.; Šobić, Dragana P.; Obradović, Vladimir B.; Del Poggio, Paolo; Serafimoski, Vladimir C. // World Journal of Gastroenterology;7/14/2009, Vol. 15 Issue 26, p3269 

    AIM: To estimate the characteristics of Color Doppler findings and the results of hepatic radionuclide angiography (HRA) in secondary Hodgkin's hepatic lymphoma. METHODS: The research included patients with a diagnosis of Hodgkin's lymphoma with metastatic focal lesions in the liver and...

  • Hodgkin's Disease. Vohr, Hans-Werner // Encyclopedic Reference of Immunotoxicology;2005, p291 

    A definition of the term "Hodgkin's disease" is presented. It refers to a malignant disease, a form of lymphoma, characterized by enlargement of the lymph nodes, spleen and liver.

  • Lymphoma: An update on evolving trends in staging and management. Dailey, Seth H.; Sataloff, Robert T. // ENT: Ear, Nose & Throat Journal;Mar2001, Vol. 80 Issue 3, p164 

    Because lymphoma frequently manifests as a neck mass, otolaryngologists are often the first to evaluate and diagnose it. Excisional biopsy of lymph nodes generally provides the definitive diagnosis. After diagnosis, however, the otolaryngologist's involvement generally wanes as subsequent...

  • Combination Chemotherapy of Lymphomas Other Than Hodgkin's Disease. Stein, Richard S.; Moran, Edgar M.; Desser, Richard K.; Miller, J. Bruce; Golomb, Harvey M.; Ultmann, John E. // Annals of Internal Medicine;Nov74, Vol. 81 Issue 5, p601 

    Presents a study which compared the efficacy and toxicity of two regimens of combination therapy in patients with lymphomas, other than Hodgkin's disease. Method of the study; Results and discussion; Conclusion.

  • Economics of stem cell transplantation for lymphoma: counting the cost of living. Sweetenham, J W // British Journal of Cancer;1/1/2000, Vol. 82 Issue 1, p4 

    Editorial. Examines the effectiveness of high dose therapy (HDT) and autologous stem cell transplantation (ASCT) for the treatment of patients with hodgkin's disease and non-hodgkin's lymphoma. Increase in the number of ASCT procedures; Cost effectiveness of these therapies; Reference related...

  • A lesson from grandma. Nagler, Willibald // Cortlandt Forum;03/25/97, Vol. 10 Issue 3, p65 

    Recounts the author's experiences diagnosing a patient with cat-scratch disease. Similarity between the symptoms of cat-scratch and Hodgkin's lymphoma.

  • Hodgkin on Hodgkin's Disease. Hodgkin, Thomas // Annals of Internal Medicine;Jun72, Vol. 76 Issue 6, p980 

    Provides information on Hodgkin's disease. Clinical manifestation of the disease; Mechanism of inflammation.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics