Cytotoxic T lymphocyte antigen—4 gene polymorphisms do not confer susceptibility to autoimmune hepatitis types 1 and 2 in Brazil

Bittencourt, Paulo L.; Palácios, Selma A; Cançado, Eduardo L.R.; Porta, Gilda; Carrilho, Flair J.; Laudanna, Antonio A.; Kalil, Jorge; Goldberg, Anna C.
July 2003
American Journal of Gastroenterology;Jul2003, Vol. 98 Issue 7, p1616
Academic Journal
: ObjectivesSusceptibility to autoimmune hepatitis (AIH) has been linked to different HLA-DR antigens in distinct populations. Recently, an A–G polymorphism in exon 1 of the cytotoxic T lymphocyte antigen-4 (CTLA-4) gene was associated with predisposition to AIH type 1 (AIH-1) in white individuals in North America. This polymorphism has been associated with several other autoimmune diseases, presumably because of its effect in the expression of CTLA-4, an adhesion molecule that downregulates peripheral T cell responses. The aims of this study were to assess the frequency of CTLA-4 genotypes in Brazilian patients with AIH-1 and AIH type 2 (AIH-1), as well as to investigate the influence of these genotypes in disease expression.: MethodsDetermination of CTLA-4 genotypes was carried out in 106 patients with AIH-1, 26 subjects with AIH-2, and 67 healthy control subjects by polymerase chain reaction (PCR)–based techniques.: ResultsNo difference in the distribution of CTLA-4 genotypes was observed in subjects with AIH-1 and AIH-2 as compared to healthy controls. Patients with AIH-1 and AIH-2 with the GG genotype exhibited lower γ-globulin and ALT levels, respectively.: ConclusionsSusceptibility to AIH-1 and AIH-2 in Brazilian patients is not influenced by exon 1 CTLA-4 gene polymorphisms at position 49.


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