TITLE

Interferon monotherapy for dialysis patients with chronic hepatitis C: an analysis of the literature on efficacy and safety

AUTHOR(S)
Russo, Mark W.; Goldsweig, Craig D.; Jacobson, Ira M.; Brown Jr., Robert S.
PUB. DATE
July 2003
SOURCE
American Journal of Gastroenterology;Jul2003, Vol. 98 Issue 7, p1610
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
: ObjectivesHepatitis C virus (HCV) is prevalent in patients with end stage renal disease who are on dialysis. Liver disease from HCV is a cause of substantial morbidity and mortality after kidney transplantation in infected recipients. Effective treatment of chronic HCV is needed in this group of patients. We aimed to determine from the literature the efficacy and safety of interferon monotherapy in dialysis patients with chronic HCV.: MethodsWe reviewed the literature from 1986 to 2001 on the efficacy of interferon monotherapy in patients with HCV and end stage renal disease who were on dialysis. The outcomes measured were sustained viral response (SVR) and drop-out rate.: ResultsWe reviewed 17 studies, of which 11 studies with a total of 213 patients met criteria for our analysis. Eight studies evaluated 3 million units (MU) three times/wk (t.i.w.), and three studies evaluated higher doses. The pooled SVR for 3 MU was 33% (95% CI = 21–51%). The pooled SVR for genotype 1 patients was 26% (95% CI = 15–37%). Of 152 patients in eight studies treated with 3 MU t.i.w. of interferon monotherapy, 45 patients (29.6%) discontinued therapy because of side effects.: ConclusionsOur analysis suggests that interferon monotherapy is more effective in patients on dialysis than in patients with normal renal function. Interferon monotherapy is associated with more adverse events in dialysis patients. The optimal dose and duration of interferon monotherapy and selection criteria of dialysis patients need to be studied further in clinical trials.
ACCESSION #
10234256

 

Related Articles

  • Transplantation.  // Kidney;Mar/Apr2000, Vol. 9 Issue 2, p77 

    Presents several abstracts of research on renal transplantation. 'Histologic Picture Signals Prognosis in Dense Deposit Disease'; 'Hypoalbuminemia May Identify Increased Risk for Graft Loss'; 'Aggressive Use of Aged Donor Kidneys Urged.'

  • Transplantation.  // Kidney;May/Jun2000, Vol. 9 Issue 3, p123 

    Presents abstracts of several studies on kidney transplantation. 'Economic Implications of HLA Matching in Cadaveric Renal Transplantation,' by M.A. Schitzler, et al; 'Features of Acute Rejection That Increase Risk for Chronic Rejection,' by A. Humar, et al; ' Outcome of Transplantation of...

  • Immune Complex Nephropathy in Schistosomiasis. Falcao, Horacio A.; Gould, Daniel B. // Annals of Internal Medicine;Aug75, Vol. 83 Issue 2, p148 

    Describes the case of a patient afflicted with chronic hepatosplenic schistosomiasis and renal disease and who received a kidney transplant. Medical history of the patient; Treatment given to the patient; Cause of renal diseases.

  • Renal Carcinoma in a Cadaver Kidney Graft Donor. Baird, R.N.; White, H.J.O.; Tribe, C.R. // British Medical Journal;5/17/1975, Vol. 2 Issue 5967, p371 

    Describes the accidental transplantation of a kidney containing renal carcinoma in a cadaver kidney graft donor in Great Britain. Abandonment of kidney transplantation with primary malignant disease; Assessment on the risk of transplanting kidney containing malignant tumor; Need of removing any...

  • Nature and mediators of renal lesions in kidney transplant patients given cyclosporine for more than one year. BENIGNI, ARIELA; BRUZZI, ISABELLA; MISTER, MARILENA; AZZOLLINI, NADIA; GASPARI, FLAVIO; PERICO, NORBERTO; GOTTI, ELIANA; BERTANI, TULLIO; REMUZZI, GIUSEPPE // Kidney International;Feb1999, Vol. 55 Issue 2, p674 

    Nature and mediators of renal lesions in kidney transplant patients given cyclosporine for more than one year. Background. Cyclosporine (CsA) has improved patients and organ-graft survival rates, but its chronic nephrotoxicity is still an issue. Although prolonged vasoconstriction could...

  • APAs Play Role in Pathogenesis of Thrombosis.  // Kidney;Sep/Oct99, Vol. 8 Issue 5, p211 

    Discusses an abstract of the article, entitled 'Prevalence and clinical significance of antiphospholipid antobodies in renal transplant recipients,' by P. Ducloux, E.M. Pellet, V. Fournier and others, published in the 1999 journal of the 'Transplantation'.

  • Race: An Important Factor for Graft Survival in Children with FSGS.  // Kidney;Sep/Oct99, Vol. 8 Issue 5, p213 

    Discusses an abstract of the article, entitled 'Predictive value of race in post-transplantation recurrence of focal segmental glomerulosclerosis in children,' by L. Butani, M.S. Polinsky, B.A. Kaiser and others.

  • Predictors of GBV-C infection among patients referred for renal transplantation. Murthy; Muerhoff, A. Scott; Desai, Suresh M.; Natov, Svetlozar N.; Bouthot, Beth A.; Ruthazer, Robin; Schmid, Christopher H.; Levey, Andrew S.; Mushahwar, Isa K.; Pereira, Brian J.G. // Kidney International;Jun1998, Vol. 53 Issue 6, p1769 

    Predictors of GBV-C infection among patients referred for renal transplantation. The etiology of liver disease remains unknown in about 4 to 23% of dialysis patients and 10 to 16% of renal transplant recipients. A search for other causative agents of liver disease led to the discovery of the GB...

  • Trasplante hep�tico ortot�pico. Resultados en un centro de trasplantes. Mendoza-S�nchez, Federico; Haro-Haro, Francisco Javier; Sandoval-Alvarado, Jes�s; Zepeda-Gonz�lez, Alonso; Herrera-Rodr�guez, Roberto; Bassols-Ricardez, �ngel // Cirugia y Cirujanos;jul/ago2007, Vol. 75 Issue 4, p281 

    Background: We undertook this study to describe the results of hepatic orthotopic transplant. Patient characteristics, implants, and patient evolution after transplant were studied. The study was conducted at a third-level medical facility in Mexico. Methods: The files of 49 patients who had a...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics