Hypercalcemia and distal renal tubular acidosis: an association not only in the newborn

Pela, Ivana; Seracini, Daniela; Lavoratti, Giancarlo; Materassi, Marco
August 2003
Pediatric Nephrology;Aug2003, Vol. 18 Issue 8, p850
Academic Journal
Distal renal tubular acidosis is a possible etiology of hypercalcemia in newborn children. Hypercalcemia in newborn infants with distal renal tubular acidosis is probably due to calcium overload secondary to acidosis-induced bone dissolution and to incomplete excretion of the endogenous calcium load because of the reduced glomerular function characteristic of the newborn period. Severe dehydration increases the calcium reabsorption by the proximal tubule as occurs during diuretic therapy with thiazide derivatives.


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