TITLE

Inflammatory myofibroblastic tumors of the nasal cavity and paranasal sinus: a clinicopathologic study of 25 cases and review of the literature

AUTHOR(S)
He, Chun-yan; Dong, Ge-hong; Yang, Dong-mei; Liu, Hong-gang
PUB. DATE
April 2015
SOURCE
European Archives of Oto-Rhino-Laryngology;Apr2015, Vol. 272 Issue 4, p789
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Inflammatory myofibroblastic tumor (IMT) is rare in nasal cavity and paranasal sinus. The aim of this study was to describe the clinicopathological features of sinonasal IMT and analyze the relationship between the clinicopathological features and the prognosis. A retrospective study of 25 IMT patients between 2001 and 2012 was performed. Data on clinical features, treatment, and follow-up were recorded. The histological characters were observed. Overall survival (OS) and event-free survival (EFS) were estimated using the Kaplan-Meier method. Clinically, the most common symptoms were nasal obstruction, facial pain, and toothache. Twenty patients received follow-ups 6-120 months after initial diagnosis. Fifteen (75 %) developed recurrence 1 or more times. One patient had left cervical lymph node metastasis (5 %). Five patients died of the tumor (25 %). Histologically, the IMTs composed of bland spindle cells admixed with a prominent infiltrate of plasma cells and lymphocytes and showed obvious atypia in recurrent cases. Histology with necrosis, mitosis (≥1/10 HPF), ganglion-like cells, histological pattern I or II and relapse (≥4 times) was significantly associated with poor OS and EFS. IMT of the nasal cavity and paranasal sinuses exhibits relatively bland histologic appearances, but can shows strongly aggressive behavior and relatively poor outcomes. Multiple relapse, necrosis, frequent mitosis, the presence of ganglion-like cells, and histological pattern might be associated with poor clinical outcomes.
ACCESSION #
101643622

 

Related Articles

  • Paraseptal Structural Changes and Chronic Sinus Disease in Relation to the Deviated Septum. Elahi, Mohammed M.; Frenkiel, Saul; Fageeh, Nasser // Journal of Otolaryngology;Jul/Aug1997, Vol. 26 Issue 4, p236 

    Examines paraseptal structural changes and chronic sinus disease in relation to the deviated septum, using computerized tomography. Association of nasal-septal deviations with incidence of ostiomeatal complex obstruction; Percentage of middle-turbinate and lateral nasal-wall abnormalities;...

  • THE BASICS: Sinusitis. Hashmi, Taqi // GP: General Practitioner;4/18/2008, p24 

    The article offers information on sinusitis, an inflammatory state of the paranasal sinuses brought about by nasal cavity inflammation. The disease is classified into acute sinusitis, which lasts less than three weeks, and chronic sinusitis, which lasts more than three months. Clinical diagnosis...

  • PARANASAL SINUSES AND NASAL CAVITY; THE NOTORIOUS NEIGHBOURS OF ORBIT. Malik, Tayyaba Gul; Farooq, Khalid; Rashid, Anjum // Professional Medical Journal;Jan2011, Vol. 18 Issue 1, p154 

    Objectives: To describe the clinical and neuro-radiological patterns of orbital invasion by the sino-nasal diseases. Study Design: Descriptive, Retrospective study. Period: 2004 to 2009. Subjects and Methods: We retrospectively reviewed fifty four cases of nasal and paranasal sinus diseases...

  • PRACTICE DIARY. Brown, Sanford J. // Family Practice Management;May2005, Vol. 12 Issue 5, p86 

    Describes the case of a 61-year-old patient with a history of chronic sinusitis and presented with numbness in her eyes, and tingling and itching lips. Pathology; Symptoms; Results of physical examination; Prognosis.

  • Sinonasal Undifferentiated Carcinoma. Kerrebijn, Jeroen D. F.; Tietze, Linda; Mock, David; Freeman, Jeremy L. // Journal of Otolaryngology;Jan/Feb1998, Vol. 27 Issue 1, p40 

    This article presents a case of a patient with sinonasal undifferentiated carcinoma. This disease is a rare and highly aggressive malignancy of the nasal cavity and paranasal sinuses. Medical history of the patient is presented. The patient was treated with CAPABLE chemotherapy, followed by...

  • Anatomic Risk Factors for Sinus Disease: Fact or Fiction? Caughey, Robert J.; Jameson, Mark J.; Gross, Charlie W.; Han, Joseph K. // American Journal of Rhinology;Jul/Aug2005, Vol. 19 Issue 4, p334 

    Background: Sinonasal anatomic variants have been postulated as a risk factor for sinus disease. Therefore, a study was conducted to examine the correlation of sinus disease to septal deviation, concha bullosa, and infraorbital ethmoid cells. Methods: Two hundred fifty consecutive sinus and...

  • NON-MALIGNANT LESIONS; CLINICO-PATHOLOGICAL PROFILE OF NASAL CAVITY AND PARANASAL SINUSES. Soomro, Aftab Ahmed; Magsi, Pirbux; Sangi, Hamid Ali; Chand, Haresh // Professional Medical Journal;2014, Vol. 21 Issue 1, p191 

    Background: The presence of a mass in the nasal cavity and paranasal sinuses may seem to be simple problem, but it is very difficult to differentiate clinically from potentially malignant tumors. Objective: To evaluate the clinical presentation and histopathological features of the non malignant...

  • Saline Nasal Irrigation for Sinus Problems.  // American Family Physician;11/15/2009, Vol. 80 Issue 10, p1121 

    The article offers information on the use of saline nasal irrigation in rinsing nasal cavity to relieve sinus problems including runny nose. It explains the steps of administering nasal irrigation to patients using a nasal cup and saline salt packs. It recommends doing one nasal irrigation per...

  • Przypadek respiratory epithelial adenomatoid hamartoma (REAH) jam nosa i zatok przynosowych. Markowski, Jarosław; Gierek, Tatiana; Świderek, Monika; Pająk, Jacek; Witkowska, Małgorzata; Liszka, Łukasz; Wardas, Piotr // Otorynolaryngologia;Mar2012, Vol. 11 Issue 1, p27 

    Hamartoma is a rare, non-neoplastic tumour consisting of well differentiated tissues typical to organ in which it arises but dislocated within the tumour in a chaotic manner, often in abnormal proportions. Hamartoma, and more specifically its epithelial type, is classified into three subtypes:...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics