TITLE

Molecular mechanism of mitochondrial calcium uptake

AUTHOR(S)
Wang, Lele; Yang, Xue; Shen, Yuequan
PUB. DATE
April 2015
SOURCE
Cellular & Molecular Life Sciences;Apr2015, Vol. 72 Issue 8, p1489
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Mitochondrial calcium uptake plays a critical role in various cellular functions. After half a century of extensive studies, the molecular components and important regulators of the mitochondrial calcium uptake complex have been identified. However, the mechanism by which these protein molecules interact with one another and coordinate to regulate calcium passage through mitochondrial membranes remains elusive. Here, we summarize recent progress in the structural and functional characterization of these important protein molecules, which are involved in mitochondrial calcium uptake. In particular, we focus on the current understanding of the molecular mechanism underlying calcium through two mitochondrial membranes. Additionally, we provide a new perspective for future directions in investigation and molecular intervention.
ACCESSION #
101642180

 

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