TITLE

Attachment of DNA probes on gallium arsenide surface

AUTHOR(S)
Mohaddes-Ardabili, Ladan; Martınez-Miranda, Luz J.; Silverman, Joseph; Christou, Aristos; Salamanca-Riba, Lourdes G.; Al-Sheikhly, Mohamad; Bentley, William E.; Ohuchi, F.
PUB. DATE
July 2003
SOURCE
Applied Physics Letters;7/7/2003, Vol. 83 Issue 1, p192
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Chemical attachment of the thiol-derivatized DNA monolayers on arsenic terminated GaAs (001) has been achieved. The sulfur-As-based covalent bonds of the thiolated oligonucleotids on the arsenic terminated GaAs (001) were observed using x-ray photoelectron spectroscopy. The purpose of our work is to investigate the self-assembly of thiol-derivatized single-stranded DNA oligonucleotides (probes) on GaAs substrate. In this letter, we demonstrate that both the S-H group in the thiolated single-strand DNA, and the N-H group in the DNA bases are functional groups that can be utilized to anchor the DNA molecule, or other biological molecules on the As-terminated GaAs surface.
ACCESSION #
10143717

 

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