TITLE

Circular DNA Unwound by Photoproducts other than Pyrimidine Dimers

AUTHOR(S)
Ciarrocchi, Giovanni; Sutherland, Betsy M.
PUB. DATE
January 1984
SOURCE
BioScience;Jan1984, Vol. 34 Issue 1, p45
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Discusses circular DNA unwound by photoproducts other than pyrimidine dimers. UV radiation's production of mutagenic lesions caused by solar radiation in prokaryotes; Altered tertiary structure of modified DNA; Alteration of the electrophoretic pattern of DNA.
ACCESSION #
10132050

 

Related Articles

  • Repeated exposures of human skin equivalent to low doses of ultraviolet-B radiation lead to changes in cellular functions and accumulation of cyclobutane pyrimidine dimers. Chouinard, Nadine; Therrien, Jean-Philippe; Mitchell, David L; Robert, Marielle; Drouin, Régen; Rouabhia, Mahmoud // Biochemistry & Cell Biology;Aug2001, Vol. 79 Issue 4, p507 

    Chronic exposure to sunlight may induce skin damage such as photoaging and photocarcinogenesis. These harmful effects are mostly caused by ultraviolet-B (UVB) rays. Yet, less is known about the contribution of low UVB doses to skin damage. The aim of this study was to determine the tissue...

  • Individual Photosensitivity of Human Skin and UVA-Induced Pyrimidine Dimers in DNA. Mouret, Stéphane; Leccia, Marie-Thérèse; Bourrain, Jean-Luc; Douki, Thierry; Beani, Jean-Claude // Journal of Investigative Dermatology;Jul2011, Vol. 131 Issue 7, p1539 

    Delineation of the DNA-damaging properties of UVA radiation is a major issue in understanding solar carcinogenesis. Emphasis was placed in this study on the formation of cyclobutane pyrimidine dimers (CPDs), which are now well established as the most frequent UVA-induced DNA lesions in human...

  • Production of Pyrimidine Dimers in DNA of Human Skin Exposed In Situ to UVA Radiation. Freeman, Steven E.; Gange, Richard W.; Sutherland, John C.; Matzinger, Ezra A.; Sutherland, Betsy M. // Journal of Investigative Dermatology;Apr87, Vol. 88 Issue 4, p430 

    Cyclobutyl pyrimidine dimers, measured as sites recognized by the dimer-specific ultraviolet (UV) endonuclease from Micrococcus luteus, were produced in DNA of human skin exposed in situ to UVA (320-400 nm) radiation. The dimer yields produced by a broadband UVA source, by broadband UVA...

  • Light-driven DNA repair by photolyases. Essen, L. O.; Klar, T. // Cellular & Molecular Life Sciences;Jun2006, Vol. 63 Issue 11, p1266 

    DNA photolyases are highly efficient light-driven DNA repair enzymes which revert the genomedamaging effects caused by ultraviolet (UV) radiation. These enzymes occur in almost all living organisms exposed to sunlight, the only exception being placental mammals like humans and mice. Their...

  • Photoreactivation in Bacteria and in Skin. Sutherland, Betsy M. // Journal of Investigative Dermatology;Jul81, Vol. 77 Issue 1, p91 

    In many procaryotic and eucaryotic cells, photoreactivating enzyme mediates light-dependent repair of UV- induced damage: the enzyme binds to a pyrimidine dimer in DNA, and, on absorption of a photon (300-600 nm), specifically monomerizes the dimer, thus repairing the DNA. Photoreactivating...

  • The in Vivo Characterization of Translesion Synthesis Across UV-Induced Lesions in Saccharomyces cerevisiae Insights Into Poζ-and Polη-Dependent Frameshift Mutagenesis. Abdulovic, Amy L.; Jinks-Robertson, Sue // Genetics;Mar2006, Vol. 172 Issue 3, p1487 

    UV irradiation, a known carcinogen, induces the formation of dipyrimidine dimers with the predominant lesions being cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6-4) pyrimidone adducts (6-4PPs). The relative roles of the yeast translesion synthesis DNA polymerases Polζ and Polη in...

  • Inhibition of Mixed Leukocyte Culture Reaction by 8-Methoxypsoralen and Long-wavelength Ultraviolet Radiation. Kraemer, Kenneth H.; Levis, William R.; Cason, Joseph C.; Tarone, Robert E. // Journal of Investigative Dermatology;Aug81, Vol. 77 Issue 2, p235 

    Psoriasis patients receiving therapy with oral 8-methoxypsoralen plus long-wavelength ultraviolet radiation have been reported to have diminished leukocyte DNA synthesis and immune reactivity. In order to quantitate the immunological effects of therapeutic concentrations of 8-methoxypsoralen...

  • Histone Modifications Induced by Chemicals and Photogenotoxicity. Yuko Ibuki // Genes & Environment;2014, Vol. 36 Issue 3, p111 

    Photogenotoxicity is generally defined as the ability of chemicals to induce genotoxic effects under ultraviolet (UV) and/or visible light. The potential of chemically-induced epigenetic alterations in the nucleus to affect the genotoxicity of UV has been discussed in this review. UV induces the...

  • Repair of Ultraviolet Light Damage to the DNA of Cultured Human Epidermal Keratinocytes and Fibroblasts. Taichman, Lorne B.; Setlow, Richard B. // Journal of Investigative Dermatology;Sep79, Vol. 73 Issue 3, p217 

    Pure cultures of dermal fibroblasts and epidermal keratinocytes have been obtained from a single biopsy of newborn foreskin. The cells were labeled, exposed to several doses of UV light, and allowed to repair in the dark for 16 hr. The number of pyrimidine dimers before and after repair was...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics