Perception of Antiretroviral Generic Medicines: One-Day Survey of HIV-Infected Patients and Their Physicians in France

Jacomet, Christine; Allavena, Clotilde; Peyrol, Fleur; Pereira, Bruno; Joubert, Laurence Morand; Bagheri, Haleh; Cotte, Laurent; Garaffo, Rodolphe; Gerbaud, Laurent; Dellamonica, Pierre
February 2015
PLoS ONE;Feb2015, Vol. 10 Issue 2, p1
Academic Journal
Background: In the interest of cost effectiveness, switching antiretroviral brand name medications to generics is recommended in France since 2013. The study objective was to evaluate the perception of generics per se and antiretroviral generics in HIV-infected patients and their hospital physicians Methods and Findings: 556 out of 703 (79%) adult HIV+ outpatients and 116 physicians in 33 clinics were included in a multicentric cross-sectional survey performed in September 2013. Patients completed a self-questionnaire on their perception and acceptability of generics. Physicians completed a questionnaire on their acceptability of switching antiretroviral to generic. Socio-demographic data, medical history and HIV history were collected. Among the 556 patients with a median HIV duration of 13 years, 77% were France native, 59% in active employment, 100% covered by social insurance, 95% on antiretroviral therapy. Seventy-six percent of the patients accepted generics and 55% trusted them overall. Antiretroviral generics were accepted by 44% of them but only by 17% if the pill burden was going to increase. The factor significantly associated with acceptability of antiretroviral generics was acceptance of generics per se (p<0.001). Among the 116 physicians following a median of 100 HIV-patients/year, 75% would prescribe generics, dropping to 26% if the combo had to be broken. Factors significantly associated with willingness to prescribe antiretroviral generics were the absence of concern regarding the chemical entity (OR = 0.33), being aware that the patient would accept generics for other pathologies (OR = 2.04) and would accept antiretroviral generics (OR = 1.94). No factor related to sociodemographic conditions, HIV status or comorbidities was associated with the acceptability of antiretroviral generics. Conclusions: Acceptability of antiretroviral generics in this French population was mostly dictated by the patient’s and physician’s knowledge and use of generics overall. It should be improved with an efficient information of both patients and physicians.


Related Articles

  • Prevalence and factors associated with idiopathic hypercalciuria in HIV patients on combination antiretroviral therapy. Pocaterra, D.; Carenzi, L.; Ricci, E.; Minisci, D.; Schiavini, M.; Gervasoni, C.; Meraviglia, P.; Bevilacqua, M.; Rizzardini, G.; Bonfanti, P. // International Journal of STD & AIDS;Dec2010, Vol. 21 Issue 12, p829 

    Idiopathic hypercalciuria may lead to bone loss via three pathogenic mechanisms described in HIV-negative patients: intestinal hyperabsorption, kidney loss and bone hyperabsorption. We conducted a cross-sectional study in a cohort of 217 HIV-positive antiretroviral-experienced patients,...

  • Prevalence of Dyslipidemia and Metabolic Abnormalities in HIV-Infected Patients. Ramezani, Amitis; Mohraz, Minoo; Yadegarinia, Davood; Banifazl, Mohammad; Gachkar, Latif; Jam, Sara; Aghakhani, Arezoo; Eslamifar, Ali; Yaghmaie, Farhad; Nemati, Kambiz; Velayati, Ali Akbar // Acta Medica Iranica;2009, Vol. 47 Issue 2, p83 

    Dyslipidemia has become a common problem in human immunodeficiency virus (HIV) disease, especially in patients on combination antiretroviral therapy. We investigated the prevalence of and factors associated with dyslipidemia in HIV-infected patients in Iran. In this cross-sectional study, 190...

  • General practitioner attitudes to prescribing hepatitis C antiviral therapy in a community setting. Lambert, Stephen M.; Page, Andrew N.; Wittmann, Johannes; Hayllar, Jeremy S.; Ferndale, Clint W.; Bain, Tanya M.; Macdonald, Graeme A. // Australian Journal of Primary Health;Sep2011, Vol. 17 Issue 3, p282 

    There is a growing debate about the prescription of hepatitis C virus (HCV) antiviral therapies within a community setting in Australia. This study aimed to identify interest and confidence among general practitioners (GPs) in prescribing HCV antiviral therapy in a community setting. Data from...

  • A cross-sectional, population-based study measuring comorbidity among people living with HIV in Ontario. Kendall, Claire E.; Wong, Jenna; Taljaard, Monica; Glazier, Richard H.; Hogg, William; Younger, Jaime; Manuel, Douglas G. // BMC Public Health;2014, Vol. 14 Issue 1, p1 

    Background As people diagnosed with HIV and receiving combination antiretroviral therapy are now living longer, they are likely to acquire chronic conditions related to normal ageing and the effects of HIV and its treatment. Comordidities for people with HIV have not previously been described...

  • Lesiones orales en pacientes VIH/SIDA asociadas a tratamiento antirretroviral y carga viral. Harris Ricardo, Jonathan; Rebolledo Cobos, Martha; Díaz Caballero, Antonio José // Salud Uninorte;sep-dic2012, Vol. 28 Issue 3, p373 

    Objective: To determine the association between oral manifestations of HIV/AIDS patients with antiretroviral therapy and viral load. Matherials and Methods: Cross-sectional study with 166 patients in Cartagena (Colombia). For collection of information, it was taken like norms the concepts of the...

  • ARTERIAL STIFFNESS IN HIV INFECTED PATIENTS. Papiță¹, Anamaria; Albu², Adriana; Fodor², Daniela; Itu¹, Corina; Cârstina³, D. // Therapeutics, Pharmacology & Clinical Toxicology;2011, Vol. 15 Issue 2, p111 

    Background: Cardiovascular disease is an increasing cause of morbidity and mortality in HIV-infected patients. The increased cardiovascular risk in HIV infected patients is linked to traditional risk factors but also to HIV infection itself which can damage the arterial wall. The antiretroviral...

  • THE DEPRESSION PROFILE OF PEOPLE LIVING WITH HIV/AIDS (PLWHA) RECEIVING ANTIRETROVIRAL TREATMENT IN DR. SOETOMO HOSPITAL SURABAYA. Manurung, Yosua Hendriko; Maramis, Margarita Maria; Triyono, Erwin Astha // Folia Medica Indonesiana;2014, Vol. 50 Issue 1, p6 

    It is important to know the profile and prevalence of depressive symptom in patients with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) which are in medication of anti retro viral (ARV) to avoid the opportunity of drugs withdrawal which can lead to the increasing of...

  • Polypharmacy and Risk of Antiretroviral Drug Interactions Among the Aging HIV-Infected Population. Holtzman, Carol; Armon, Carl; Tedaldi, Ellen; Chmiel, Joan; Buchacz, Kate; Wood, Kathleen; Brooks, John // JGIM: Journal of General Internal Medicine;Oct2013, Vol. 28 Issue 10, p1302 

    BACKGROUND: Among aging HIV-infected adults, polypharmacy and its consequences have not been well-described. OBJECTIVE: To characterize the extent of polypharmacy and the risk of antiretroviral (ARV) drug interactions among persons of different ages. DESIGN AND PARTICIPANTS: Cross-sectional...

  • Development of Metabolic Risk Factors after Initiation of Second Line Anti-Retroviral Therapy. MITTAL, APOORVA; BASAVAPRABHU, A. // Australasian Medical Journal;Apr2013, Vol. 6 Issue 4, p241 

    Introduction Highly Active Anti-Retroviral Therapy (HAART) is accompanied with several metabolic effects like adipose redistribution and insulin resistance. HAART has reduced the number of deaths but is associated with increased risk of strokes and heart attacks. We did this study to examine the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics