TITLE

The skinny on neurotrophins

AUTHOR(S)
Wisse, Brent E; Schwartz, Michael W
PUB. DATE
July 2003
SOURCE
Nature Neuroscience;Jul2003, Vol. 6 Issue 7, p655
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Obesity and its comorbid illnesses are a leading world health concern for which few effective treatments exist. Obesity is increasingly viewed as a disorder of energy homeostasis, a regulatory process that involves hormones such as insulin and leptin that circulate at levels proportionate to body fat content and act on neurons in the hypothalamus and elsewhere to reduce food intake and body fat stores. Among hypothalamic systems, melanocortin pathway is critical in the control of body fat content. Consequently, interventions that reduce body adiposity, and hence, lower plasma leptin levels, such as a calorie-restricted diet, are hypothesized to stimulate the drive to eat, in part, by inhibiting pro-opiome-lanocortin neurons and by activating neuropeptide Y⁄agouti-related peptide neurons, a combination that decreases hypothalamic melanocortin signaling.
ACCESSION #
10121819

 

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