Cardiopulmonary bypass is not associated with increased jugular venous blood free radical activity

Ip-Yam, P C; Browning, P G; Behl, S
March 2003
Perfusion;Mar2003, Vol. 18 Issue 2, p123
Academic Journal
We have measured jugular venous oxygen saturation (sjv[SUBO[SUB2]]) and lactate, arterial and jugular venous blood levels of lipid peroxidation products - malondialdehyde (MDA) and diene conjugates as an index of free radical activity in eight adults undergoing coronary artery bypass surgery. Measurements were carried out at six specific times: T1 -- within 5 min before cardiopulmonary bypass (CPB), T2 -- within the first minute after the commencement of CPB, T3 -- during stable temperature (28°C) on CPB, T4 -- during rewarming at 34°C, T5 -- 15 min after CPB and T6 -- at skin closure. There were no significant changes in arterial, jugular venous and arterio-jugular venous (a-jv) differences in diene conjugates and MDA. There was no correlation between sjv[SUBO[SUB2]], lactate and a-jv differences in MDA and diene conjugates. These results are not indicative of ischaemia-reperfusion injury across the cerebral circulation during hypothermic CPB.


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