Comparative current–voltage characteristics of nicked and repaired λ-DNA

Hartzell, B.; McCord, B.; Asare, D.; Chen, H.; Heremans, J. J.; Soghomonian, V.
June 2003
Applied Physics Letters;6/30/2003, Vol. 82 Issue 26, p4800
Academic Journal
We report on current-voltage characteristics obtained at room temperature on λ-DNA molecules, modified at both ends with disulfide groups and spanning Au electrodes. A comparison is drawn between the characteristics of the λ-DNA, which after modification features a gap between 3′ and 5′ sites (nicked DNA), and λ-DNA where this gap has been ligated (repaired DNA). The repaired DNA double helices show a close-to-linear current-voltage characteristic, and a dc conductivity estimated at ∼1×10[SUP-3] S cm[SUP-1]. In contrast, the nicked DNA shows pronouncedly nonlinear and rectifying behavior, with a conductivity gap of ∼3 eV. The low-field conductivity of the nicked DNA is approximately a factor 20 lower than the repaired DNA's conductivity.


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