Repeated antenatal intracranial haemorrhage: magnetic resonance imaging in a fetus with alloimmune thrombocytopenia

Hidebrandt, T.; Powell, T.
November 2002
Archives of Disease in Childhood -- Fetal & Neonatal Edition;Nov2002, Vol. 87 Issue 3, p222
Academic Journal
Neonatal alloimmune thrombocytopenia is caused by transplacental passage of maternal platelet specific antibodies leading to destruction of fetal platelets. Published estimations of incidence range from 1.5 per 1000 neonates to 1 per 5000 neonates. Most intracranial haemorrhages occur in the third trimester, but early cases have been reported, possibly recurrent. The most common site of intracranial haemorrhage is beneath the cerebral cortex, with possible expansion to a subarachnoid bleed and dissection through the brain reaching the ventricles, resulting in the appearance of schizencephaly.


Related Articles

  • Neonatal alloimmün trombositopeni ve paraüretral kist birlikteliÄŸi. Kışlal, Fatih Mehmet; Akbaş, Tolga; Güveloğlu, Mine // Gulhane Medical Journal;Mar2013, Vol. 55 Issue 1, p63 

    Neonatal alloimmune thrombocytopenia (NAIT) is one of the etiological factors of severe neonatal thrombocytopenia; it is caused by feto-maternal incompatibility of "thrombocyte specific alloantigens". Intracranial hemorrhage is the most severe complication of NAIT and it can be seen in the...

  • Clinical: Clinical Review - Thrombocytopenia.  // GP: General Practitioner;1/27/2006, p51 

    The article presents information on thrombocytopenia. Thrombocytopenia is the term applied when the peripheral blood platelet count falls below 150x109/l. The problem is common in practice, but generally it presents no major clinical problems. The reason thrombocytopenia is taken so seriously is...

  • Developing recombinant HPA-1a-specific antibodies with abrogated Fcgamma receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia. Ghevaert, Cedric; Wilcox, David A.; Fang, Juan; Armour, Kathryn L.; Clark, Mike R.; Ouwehand, Willem H.; Williamson, Lorna M. // Journal of Clinical Investigation;Aug2008, Vol. 118 Issue 8, p2929 

    Fetomaternal alloimmune thrombocytopenia (FMAIT) is caused by maternal generation of antibodies specific for paternal platelet antigens and can lead to fetal intracranial hemorrhage. A SNP in the gene encoding integrin beta3 causes a clinically important maternal-paternal antigenic difference;...

  • Was therapy necessary for the neonate of a mother with idiopathic thrombocytopenic purpura? Salama, Abdulgabar // European Journal of Pediatrics;Aug2005, Vol. 164 Issue 8, p533 

    Presents a response to a comment made by Sinasi Özsoylu to the article "A therapy-Refractory Neonatal Auto-immune Thrombocytopenia Treated With Anti-D." Reasons for the increase in platelet count of an infant with thrombocytopenia; Treatment for neonates with severe immune thrombocytopenia.

  • Was therapy necessary for the neonate of a mother with idiopathic thrombocytopenic purpura? Özsoylu, Sinasi // European Journal of Pediatrics;Aug2005, Vol. 164 Issue 8, p532 

    Presents a comment to the article "A Therapy-Refractory Neonatal Auto-immune thrombocytopenia Treated With Anti-D," by G. Gaedicke, M. Cremer, O. Meyer and A. Salama published in the 2004 issue of the "European Journal of Pediatrics." Ineffectiveness of platelet transfusion in the presence of...

  • Thrombocytopenia in Neonatal Infection. Modanlou, Houchang D.; Ortiz, Oscar B. // Clinical Pediatrics;Jun1981, Vol. 20 Issue 6, p402 

    Serial platelet counts by phase microscopy were done for three groups of neonates who were admitted to the Special Care Unit of the Miller Children's Hospital. Group 1 (78 neonates) was evaluated for septicemia. Group 2 (28 neonates) was randomly selected sick neonates whose working diagnosis...

  • Serum thrombopoietin level and thrombocytopenia during the neonatal period in infants with Down's syndrome. Matsubara, K.; Nigami, H.; Yura, K.; Inoue, T.; Isome, K.; Fukaya, T. // Journal of Perinatology;Feb2010, Vol. 30 Issue 2, p98 

    Background:The pathogenesis of thrombocytopenia during the neonatal period in Down's syndrome (DS) infants remains unclear.Objective:To elucidate kinetic changes of serum thrombopoietin (TPO) level and platelet count, and their correlation in DS neonates.Study Design:Twelve DS infants...

  • Management of Pregnancy in a Chilean Patient with Congenital Deficiency of Factor VII and Glanzmann's Thrombasthenia Variant. Murray, Nigel P.; Garcia, Claudio; Ilabaca, Javier; Lagos, Nestor // Case Reports in Obstetrics & Gynecology;2014, p1 

    Patients with inherited bleeding disorders are rare in obstetric practice but present with prolonged bleeding even after minor invasive procedures. They require a combined approach with obstetric and hematological management of each case, including the neonatal management of a possibly affected...

  • Heparin.  // Reactions Weekly;11/15/2008, Issue 1228, p20 

    The article describes the case of a 49-year-old man who was diagnosed with heparin-induced thrombocytopenia (HIT) antibodies. The patient tested positive for the said condition while undergoing treatment with intravenous (IV) heparin. He was subjected to thrombectomy and was administered with...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics