Endothelin 1 concentrations in infants with meconium stained amniotic fluid

Yigit, S.; Tekinalp, G.; Oran, O.; Yordakok, M.; Aliefendioglu, D.; Gurgey, A.
November 2002
Archives of Disease in Childhood -- Fetal & Neonatal Edition;Nov2002, Vol. 87 Issue 3, p212
Academic Journal
Meconium is a viscous green liquid that consists of gastrointestinal secretions, bile, bile acids, mucus, pancreatic juice, cellular debris, swallowed vernix caseosa, lanugo, and blood; 10-15% of all babies will pass the substance prior to birth. Although some studies have shown that the majority of fetuses passing meconium are not in distress, passage of meconium has been often used as a marker of ante- or intrapartum asphyxia. Within hours of exposure to meconium, there is a profound pulmonary inflammatory response. Increased concentrations of inflammatory cytokines and endothelin 1 are produced as a result of meconium injury. These vasoactive mediators play a role in the pulmonary artery vasoconstriction of persistent pulmonary hypertension, which is frequently associated with meconium aspiration syndrome.


Related Articles

  • Managing meconium aspiration. Fuloria, Mamta; Wiswell, Thomas E. // Contemporary OB/GYN;Jul2000, Vol. 45 Issue 7, p113 

    Discusses the treatment for meconium aspiration syndrome (MAS). Dangers of meconium aspiration; Identification of MAS; Strategies for preventing meconium aspiration or lessening its effects.

  • Effects of intravenous dual endothelin-1 receptor blocker tezosentan and inhaled iloprost on acute pulmonary hypertension secondary to meconium aspiration in a porcine model.  // Cardiology in the Young;May2005 Supplement 2, Vol. 15 Issue S2, p77 

    The article focuses on a study related to the effects of intravenous dual endothelin-1 receptor blocker tezosentan and inhaled iloprost on acute pulmonary hypertension secondary to meconium aspiration in a porcine model. Acute pulmonary arterial hypertension is associated with acute lung injury...

  • Inhaled Nitric Oxide and Gentle Ventilation in the Treatment of Pulmonary Hypertension of the Newborn — a Single-Center, 5-Year Experience. Gupta, Anju; Rastogi, Shantanu; Sahni, Rakesh; Bhutada, Alok; Bateman, David; Rastogi, Deepa; Smerling, Arthur; Wung, Jen-Tien // Journal of Perinatology;Sep2002, Vol. 22 Issue 6, p435 

    OBJECTIVE: To evaluate the effect of inhaled nitric oxide (INO) in pulmonary hypertension of the newborn ( PH ) in a single center over 5 years using gentle ventilation (GV), without hyperventilation or induced alkalosis. METHODS: Data from 229 consecutive infants with PH of varied etiology...

  • Managing meconium aspiration. Fuloria, Mamta; Wiswell, Thomas E. // Contemporary Pediatrics;Apr2000, Vol. 17 Issue 4, p125 

    Focuses on the effects of meconium-stained amniotic fluid on the respiratory health of infants. Dangers of meconium aspiration; Identification of meconium aspiration syndrome (MAS); Management and monitoring of MAS. INSET: How MAS develops.

  • meconium aspiration syndrome.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1419 

    A definition of the medical term "meconium aspiration syndrome" which refers to the inhalation of meconium by an infant in utero during first few breaths after birth is presented.

  • ANTI-INFLAMMATORY DRUGS IN THE TREATMENT OF MECONIUM ASPIRATION SYNDROME. Mokra, D.; Mokry, J.; Calkovska, A. // Acta Medica Martiniana;Mar2011 Supplement, p13 

    No abstract available.

  • Steroids in full term infants with respiratory failure and pulmonary hypertension due to meconium aspiration syndrome. da Costa, David Eustace; Nair, Arun Kumar; Pai, Mangalore Govind; Al Khusaiby, Saleh Mohammed // European Journal of Pediatrics;2001, Vol. 160 Issue 3, p150 

    Abstract Persistent pulmonary hypertension of the newborn (PPHN) due to meconium aspiration syndrome (MAS), has a high morbidity and mortality especially in centres with limited access to extra-corporeal membrane oxygenation or nitric oxide therapy. In such a setting, we conducted a pilot study...

  • Short-Term Outcome of Mechanical Ventilation in Neonates. Gurubacharya, S. M.; D. R.Aryal; Misra, M.; Gurung, R. // Journal of Nepal Paediatric Society;Jan-Apr2011, Vol. 31 Issue 1, p35 

    Mechanical ventilation of newborn has been practiced for several years with several advances made in the way. As compared to the Western world and our neighbouring countries, neonatal ventilation in our country is still in its infancy. Objectives: To analyze the common indications and outcome of...

  • Meconium Aspiration in the Midtrimester Fetus: An Autopsy Study. Mortensen, Elin; Kearney, Michael Shelley // Pediatric & Developmental Pathology;Dec2009, Vol. 12 Issue 6, p438 

    We studied the incidence, severity, and significance of intrauterine meconium aspiration (IUMA) in the midtrimester fetus. Lung sections from 219 midtrimester fetuses were examined for meconium, identified by finding meconium corpuscles. There were 21 cases (9.6%) with IUMA. Gestational age...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics