TITLE

Endothelin 1 concentrations in infants with meconium stained amniotic fluid

AUTHOR(S)
Yigit, S.; Tekinalp, G.; Oran, O.; Yordakok, M.; Aliefendioglu, D.; Gurgey, A.
PUB. DATE
November 2002
SOURCE
Archives of Disease in Childhood -- Fetal & Neonatal Edition;Nov2002, Vol. 87 Issue 3, p212
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Meconium is a viscous green liquid that consists of gastrointestinal secretions, bile, bile acids, mucus, pancreatic juice, cellular debris, swallowed vernix caseosa, lanugo, and blood; 10-15% of all babies will pass the substance prior to birth. Although some studies have shown that the majority of fetuses passing meconium are not in distress, passage of meconium has been often used as a marker of ante- or intrapartum asphyxia. Within hours of exposure to meconium, there is a profound pulmonary inflammatory response. Increased concentrations of inflammatory cytokines and endothelin 1 are produced as a result of meconium injury. These vasoactive mediators play a role in the pulmonary artery vasoconstriction of persistent pulmonary hypertension, which is frequently associated with meconium aspiration syndrome.
ACCESSION #
10082751

 

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