TITLE

Correlation between change in pulmonary function and suppression of reactive nitrogen species production following steroid treatment in COPD

AUTHOR(S)
Sugiura, H.; Ichinose, M.; Yamagata, S.; Koarai, A.; Shirato, K.; Hattori, T.
PUB. DATE
April 2003
SOURCE
Thorax;Apr2003, Vol. 58 Issue 4, p299
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Reactive nitrogen species (RNS) have a number of inflammatory actions and the production of these molecules has been reported to be increased in the airways of patients with chronic obstructive pulmonary disease (COPD), which suggests that they may be involved in the inflammatory and obstructive process in COPD. Methods: The relationship between the reduction in RNS and the improvement in pulmonary function was studied in 18 patients with COPD following steroid treatment (800 µg beclomethosone dipropionate inhalation for 4 weeks). Twelve patients were treated with inhaled steroids and the others received placebo treatment. Forced expiratory volume in 1 second (FEV[sub 1]) and airway responsiveness to histamine were measured before and after treatment. Induced sputum cells were stained with anti-nitrotyrosine antibody, a footprint of RNS, and RNS formation was assessed by measuring nitrotyrosine immunoreactivity. The immunoreactivity of inducible nitric oxide synthose (iNOS) in induced sputum and exhaled NO levels were also measured. Results: Treatment with steroids resulted in a significant reduction in both nitrotyrosine and iNOS immunoreactivity in sputum cells compared with pretreotment levels (both p<0.01). The reduction rates in both parameters were significantly related (p<0.05). The reduction in nitrotyrosine and iNOS immunoreactivity was correlated with the improvement in FEV[sub 1] (p<0.05) and airway responsiveness to histamine (p<0.01). None of the parameters was significantly changed by placebo administration. Conclusions: These results suggest that RNS may be involved in the reversible component of inflammation in COPD that is suppressed by steroids. Further studies using specific inhibitors for RNS are needed to clarify their effects on the long term progression of COPD.
ACCESSION #
10082586

 

Related Articles

  • Corticosteroids for exacerbations of COPD. Elliott, William // Infectious Disease Alert;Aug2010 Supplement, p2 

    The article discusses research published in an issue of the "Journal of the American Medical Association" regarding the effectiveness of orally administered low-dose steroids for the treatment of acute exacerbation of chronic obstructive pulmonary disease (ae-COPD).

  • The Role of Corticosteroids in Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Novak, Barbara // Critical Care Nurse;Oct2002, Vol. 22 Issue 5, p80 

    Presents information on a study that demonstrated that an 8-week course of steroids was just as effective as a 2-week course for chronic obstructive pulmonary disease (COPD) exacerbation treatment. Factors associated with the hospitalizations for COPD exacerbations; Drugs in the treatment of...

  • Does Heliox Help in COPD Exacerbations? Luks, Andrew M. // Critical Care Alert;Mar2010, Vol. 17 Issue 12, p89 

    The article presents information on a research study to investigate the effects of helium-oxygen gas mixture to non-invasive positive pressure ventilation in the treatment of chronic obstructive pulmonary disease (COPD) exacerbations.

  • Tiotropium asthma boost.  // Pulse;9/22/2010, Vol. 70 Issue 27, p4 

    The article discusses the result of a study which reveals that chronic obstructive pulmonary diseases (COPD) drug tiotropium boosts the dose of inhaled steroids in the management of adult with asthma.

  • Review Article. Lights and shadows of non-invasive mechanical ventilation for chronic obstructive pulmonary disease (COPD) exacerbations. Lopez-Campos, Jose Luis; Jara-Palomares, Luis; Muñoz, Xavier; Bustamante, Víctor; Barreiro, Esther // Annals of Thoracic Medicine;Apr-Jun2015, Vol. 10 Issue 2, p87 

    Despite the overwhelming evidence justifying the use of non-invasive ventilation (NIV) for providing ventilatory support in chronic obstructive pulmonary disease (COPD) exacerbations, recent studies demonstrated that its application in real-life settings remains suboptimal. European clinical...

  • A prospective comparison of the efficacy and safety of fully closed-loop control ventilation (Intellivent-ASV) with conventional ASV and SIMV modes. Abutbul, A.; Sviri, S.; Zbedat, W.; Linton, D. M.; van Heerden, P. V. // Southern African Journal of Critical Care;Aug2014, Vol. 30 Issue 1, p28 

    Background. Intellivent-adaptive support ventilation (ASV) is a closed-loop, fully automatic method of mechanical ventilation. This advanced mode of ventilation adjusts ventilation and oxygenation parameters according to patient weight, lung function (as assessed by the ventilator) and...

  • Sleep-Disordered Breathing and COPD: The Overlap Syndrome ... includes discussion. Owens, Robert L.; Malhotra, Atul // Respiratory Care;Oct2010, Vol. 55 Issue 10, p1333 

    Sleep-disordered breathing (mainly obstructive sleep apnea [OSA]) and COPD are among the most common pulmonary diseases, so a great number of patients have both disorders; this "overlap syndrome" causes more severe nocturnal hypoxemia than either disease alone. This common combination of OSA and...

  • Oxygen: The Kiss of Life. Nava, Stefano // Respiratory Care;Dec2011, Vol. 56 Issue 12, p1975 

    The article presents the author's insights on the study conducted by Rice and colleagues on the efficiency of two oxygen-conserving device, the AccuO2 and CR-50, for chronic obstructive pulmonary disease (COPD) patients. He says that AccuO2 had better oxygen conservation compared to CR-50. He...

  • Diagnostic Value of the Method of Chemiluminescence from Nondiluted Whole Blood In Patients with Obstructive Pulmonary Diseases. Novikov, A. K.; Lusina, O. Y.; Voeikov, V. L.; Novikov, K. N.; Chalkin, S. F. // IOMC 2008 Proceedings Book;2008, p187 

    The aim of the current study was to compare the level of reactive oxygen species (ROS) in the whole blood of patients with BA and COPD in acute attack and after treatment using the method of chemiluminescence (CL) registering from nondiluted whole blood. CL amplifiers: lucigenin, a specific...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics