TITLE

Haemochromatosis

AUTHOR(S)
Pietrangelo, A.
PUB. DATE
May 2003
SOURCE
Gut;May2003 Supplement 2, Vol. 52, pIi23
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Iron is an important component of the Earth's crust, but its own chemistry greatly limits utilization and also sets the basis for its toxicity. The capacity of readily exchanging electrons in aerobic conditions makes iron essential for fundamental cell functions, such as DNA synthesis, transport of oxygen and electrons, and cell respiration. On the other hand, as humans have no means to control iron excretion, excess iron, regardless of the route of entry, accumulates in parenchymal organs and threatens cell viability. In fact, a number of disease states (that is, iron overload diseases) attributable to genetic or acquired factors are pathogenetically linked to excess body iron stores and iron removal therapy is an effective lifesaving strategy in such circumstances.
ACCESSION #
10074562

 

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