How to identify the genetic basis of gastrointestinal and liver diseases?
- Discovery of old diseases: the molecular approach. Deltas, C. Constantinou // European Journal of Human Genetics;Jan2003, Vol. 11 Issue 1, p3
Focuses on the application of molecular genetics to the study of old diseases. Frequency of gene mutations; Differential diagnosis.
- GUEST EDITORIAL. Ha, Tom; Rees, Jonathan L. // Acta Dermato-Venereologica;Nov/Dec2000, Vol. 80 Issue 6, p401
Focuses on the developments in molecular genetics in terms of Mendelian disorders. Clinical manifestations of Mendelian disorders; Accounts on genetically complex diseases; Genetic determinants of complex diseases; Impact of technological innovations on biology.
- Molecular genetic approaches to understanding disease. Savill, John // BMJ: British Medical Journal (International Edition);01/11/97, Vol. 314 Issue 7074, p126
Part II. Examines the use of molecular genetic approaches to understand diseases. Discovering the gene responsible for a disease; Xenografting through transgenesis; Gene transfer and gene therapy.
- Evidence of a correlation between mannose binding lectin and celiac disease: a model for other autoimmune diseases. Boniotto, Michele; Braida, Laura; Baldas, Valentina; Not, Tarcisio; Ventura, Alessandro; Vatta, Serena; Radillo, Oriano; Tedesco, Francesco; Percopo, Selvaggia; Montico, Marcella; Amoroso, Antonio; Crovella, Sergio // Journal of Molecular Medicine;Apr2005, Vol. 83 Issue 4, p308
Celiac disease is a multifactorial disorder caused, in genetically susceptible patients, by the ingestion of dietary gluten. Very little is known about the genetic factors, but there is a strong association of two HLA haplotypes (DQ2 or a1*05, ÃŸ1*02 and DQ8 or a1*0301, ÃŸ1*0302) with the...
- Interleukin-10 haplotypes in Celiac Disease in the Spanish population. Núñez, Concepción; Alecsandru, Diana; Varadé, Jezabel; Polanco, Isabel; Maluenda, Carlos; Fernández-Arquero, Miguel; de la Concha, Emilio G; Urcelay, Elena; Alfonso Martínez // BMC Medical Genetics;2006, Vol. 7, p32
Background: Celiac disease (CD) is a chronic disorder characterized by a pathological inflammatory response after exposure to gluten in genetically susceptible individuals. The HLA complex accounts for less than half of the genetic component of the disease, and additional genes must be...
- HLA related genetic risk for coeliac disease. Bourgey, Mathieu; Calcagno, Giuseppe; Unto, Nadia; Gennarelli, Daniela; Margaritte-Jeannin, Pafricia; Greco, Luigi; Limongelli, Maria Giovanna; Esposito, Oscar; Marano, Caterina; Troncone, Riccardo; Spampanato, Antonella; Clerget-Darpoux, Françoise; Sacchetti, Lucia // Gut;Aug2007, Vol. 56 Issue 8, p1054
Background: Several studies have shown an elevated prevalence of coeliac disease (CD) in sibs of coeliac patients (risk 8â€“12%). Aim and method: We evaluated the risk that sibs of children with CD will also develop CD. This cohort of 188 Italian families was composed of probands with CD,...
- Genome screening of coeliac disease. Popat, S.; Bevan, S.; Braegger, C. P.; Busch, A.; O'Donoghue, D.; Falth-Magnusson, K.; Godkin, A.; Hogberg, L.; Holmes, G.; Hosie, K. B.; Howdle, P. D.; Jenkins, H.; Jewell, D.; Johnston, S.; Kennedy, N. P.; Kumar, P.; Logan, R. F. A.; Love, A. H. G.; Marsh, M. N.; Mulder, C. J. // Journal of Medical Genetics;May2002, Vol. 39 Issue 5, p328
Discusses the genome screening of families with coeliac disease. Fluorescent genotyping of the patients; Analysis of genetic linkage; Observance of strong linkage at chromosome 6p21.3.
- Organization and integration of biomedical knowledge with concept maps for key peroxisomal pathways. A.M. Willemsen; G.A. Jansen; J.C. Komen; S. van Hooff; H.R. Waterham; P.M.T. Brites; R.J.A. Wanders; A.H.C. van Kampen // Bioinformatics;Aug2008, Vol. 24 Issue 16, pi21
Motivation: One important area of clinical genomics research involves the elucidation of molecular mechanisms underlying (complex) disorders which eventually may lead to new diagnostic or drug targets. To further advance this area of clinical genomics one of the main challenges is the...
- Spoken presentations. // Journal of Medical Genetics;Sep2002 Supplement, Vol. 39, pS22
Discusses the abstract of the research paper entitled 'Clinical and molecular genetics and epigenetics of Beckwith-Wiedemann syndrome,' by Wendy N. Cooper, K.J. Wagner et al and presented during the British Human Genetics Conference at the University of York in England in September 2002.