TITLE

Endothelins in chronic diabetic complications

AUTHOR(S)
Khan, Zia Ali; Chakrabarti, Subrata
PUB. DATE
June 2003
SOURCE
Canadian Journal of Physiology & Pharmacology;Jun2003, Vol. 81 Issue 6, p622
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Endothelins are widely distributed in the body and perform several vascular and nonvascular functions. Experimental data indicate abnormalities of the endothelin system in several organs affected in chronic diabetic complications. In support of this notion, it has been shown that endothelin-receptor antagonists prevent structural and functional abnormalities in target organs of diabetic complications in animal models. Alterations of plasma endothelin levels have also been demonstrated in human diabetes. This review discusses the role of endothelins in the pathogenesis of chronic diabetic complications. The current experimental evidence suggests that endothelin-receptor antagonism may potentially be an adjuvant therapeutic tool in the treatment of chronic diabetic complications.
ACCESSION #
10068039

 

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